Which pill works best for that stuffed feeling after eating?
NCT ID NCT07174297
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study compares two drugs, acotiamide and itopride, to see which one better relieves symptoms like fullness, bloating, and early fullness after meals in people with postprandial distress syndrome. The trial will include 152 adults aged 18-70 who have been diagnosed using standard criteria. Participants will take one of the two drugs for 8 weeks, and their symptoms will be tracked using a special scale.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Acotiamide and Itopride (drugs to improve stomach emptying and reduce bloating)
- What this could lead to
- If successful, this could show which drug works better for relieving fullness, bloating, and early fullness after meals in people with functional dyspepsia.
- What could go wrong
- This is a head-to-head comparison of two existing drugs, not a new breakthrough. The trial is small (152 people) and results may not apply to everyone with the condition.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 152 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Oct 2025
An estimate. Start dates often move.
- Expected to finish
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Apr 2027
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Subjects to provide written informed consent prior to any study procedures being performed * Subjects with age 18-70 both male and female * Diagnosed with FD (PDS) by using ROME IV criteria * Subjects naive to acotiamide and Itopride for last 2 weeks * Subjects must have a normal endoscopy result within the 6 months Exclusion Criteria: * Without predominant symptoms of ulcer and GERD based on history \& endoscopy, IBS based on history \& Rome IV criteria and Chronic idiopathic nausea based on history only * Subjects taking drugs that affect gut motility, gut sensitivity, SSRI and/or acid secretion who are unable to discontinue these drugs before initiating the intervention * Subjects with chronic medical disorders potentially contributing to PDS such as chronic pancreatitis, hypothyroidism, CKD and CLD identified through clinical history, physical examination, or previous medical records * Subjects with Type I or Type II diabetes * Pregnant \& lactating mothers
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
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Other studies related to the condition(s) this trial covers.