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Acne antibiotics may reshape your Body's bacteria

NCT ID NCT02713607

Knowledge-focused Sponsor: University of California, Davis Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how the antibiotic doxycycline changes the bacteria on the skin and in the gut of people with acne. Researchers will compare these changes between acne patients and healthy volunteers. The goal is to better understand the link between acne, antibiotics, and the body's microbiome.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
doxycycline
What this could lead to
If successful, this could help explain how antibiotics change the body's bacteria in acne, potentially guiding better treatments.
What could go wrong
This is a small, early-phase study focused on understanding, not treating. Results may not lead to new therapies or apply to everyone with acne.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

30 people

The number who actually took part.

Start date

Mar 2016

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

15 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 15 and older * Subjects/parents/legal guardian is able to read and comprehend study procedure and consent forms. * Have already been prescribed Doxycycline by their physician for acne or to be eligible to be prescribed Doxycycline for acne * Have acne that is diagnosed by a board certified dermatologist. Exclusion Criteria: * Those who have received systemic antibiotics within four weeks of starting the study. * Those who have received systemic isotretinoin within six weeks of starting the study. * Those with seborrheic dermatitis, rosacea, or polycystic ovary syndrome * Those who are pregnant, prisoners or cognitively impaired. * Those subjects who are currently using proton pump inhibits (as studies have shown this may impact the gut microbiome) (4) * Those who have a BMI greater than \>30 kg/m2, as studies have shown a reduction in the variability of intestinal microbes within this population (5). * Those who have initiated or changed brand of oral contraceptive pill within 4 weeks of starting the study. * Those who have autoimmune disorders as this group has been shown to have an altered microbiome (6) * Those who have diabetes (6), immunodeficiencies (7), inflammatory bowel disease (6), hypercholesterolemia, as these groups have been shown to have altered gut microbiomes * Those who have taken oral probiotic supplements (8) within 4 weeks of starting the study * Given the nature of the instructions that need to be adhered to for accurate collection of samples and this data, non-English speaking individuals will be excluded from this pilot study. * Allergies to the tetracycline group of antibiotics * Those who do not fit the inclusion criteria

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Conditions

The condition(s) this trial relates to.

acne Acne Vulgaris

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acne vulgaris

Contacts and locations

Locations

  • UC Davis Dept of Dermatology

    Sacramento, California, 95816, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.