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Knee fluid drain or blood injection may curb arthritis after ACL tear

NCT ID NCT07142369

Disease control Sponsor: Rush University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests two procedures done before ACL surgery: draining excess knee joint fluid (arthrocentesis) or injecting platelet-rich plasma (PRP) from the patient's own blood. The goal is to see if either reduces inflammatory chemicals linked to cartilage damage. About 99 adults aged 18-50 with a recent ACL tear and swelling will take part. The results could help prevent long-term arthritis after knee injuries.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Platelet-rich plasma (PRP)
What this could lead to
If it works, this could point toward a way to reduce joint inflammation and cartilage breakdown after an ACL tear, potentially lowering the risk of post-traumatic arthritis.
What could go wrong
This is a small, early-stage study (99 people) testing a procedure, not a drug. The benefits may be modest or not show up at all, and PRP injections carry a small risk of infection or pain at the injection site.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 99 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 - 50 * English-speaking * Clinical evidence of ACL rupture with swelling * Participant must be undergoing ACL reconstruction surgery Exclusion Criteria: * Age \<18 or \>50 * Presentation \>3 weeks after initial injury * Previous traumatic ipsilateral (same side) knee injury consistent with chronic ACL tear or prior ACL surgery * \> Kellgren-Lawrence grade 2 changes on preoperative x-ray * History of hemophilia or inflammatory arthropathy (e.g., rheumatoid arthritis)

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Conditions

The condition(s) this trial relates to.

osteoarthritis Rupture

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anterior cruciate ligament (ACL) rupture Posttraumatic osteoarthritis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Rush University Medical Center

    Chicago, Illinois, 60612, United States

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