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Knee injury may also slow your brain, study finds

NCT ID NCT07163468

Knowledge-focused Sponsor: Duzce University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looked at how ACL injuries impact not just the knee but also brain activity, reaction time, and psychological readiness to return to sports. Researchers measured brain waves, reaction speed, and fear of movement in 60 male athletes. They found that athletes who had multiple ACL surgeries had more trouble with attention, slower reactions, and greater psychological barriers. The results suggest that rehab should include mental and brain-focused exercises, not just physical therapy.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If confirmed, these findings could help design better rehabilitation programs that address not just the knee but also brain function and mental readiness after ACL injury.
What could go wrong
This is a small, completed observational study with only 60 male athletes. Results may not apply to women, non-athletes, or other injury types. No treatment was tested.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

60 people

The number who actually took part.

Started

Jun 2025

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consisted of 60 male athletes aged 18 to 30 years. Participants were divided into three groups: healthy controls with no history of knee injury, athletes with primary ACL reconstruction, and athletes with revision ACL reconstruction. All were actively engaged in regular sports participation and had completed ACL rehabilitation at least 6 months prior to enrollment.

Ages

18 to 30 years

Sex

Male participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Male athletes Age between 18 and 30 years Regular participation in amateur or professional sports Completion of ACL rehabilitation (for surgical groups) at least 6 months before enrollment Ability to undergo EEG and reaction time testing Provision of signed informed consent Exclusion Criteria: History of neurological or psychiatric conditions (e.g., epilepsy, ADHD, depression) Additional lower extremity injuries or orthopedic surgeries Metal implants or scalp conditions incompatible with EEG Uncorrected visual or auditory deficits Systemic illnesses (e.g., diabetes, multiple sclerosis, neuropathy) Use of psychoactive medication Any cognitive or physical limitation interfering with testing procedures Female participants (to avoid hormonal confounding effects on EEG recordings)

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Conditions

The condition(s) this trial relates to.

Anterior Cruciate Ligament Injuries Athletic Injuries injury Kinesiophobia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anterior cruciate ligament injuries Neurocognitive function Sports injury

Contacts and locations

Locations

  • Duzce University

    Düzce, 81620, Turkey (Türkiye)

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