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Altitude drug may protect Women's lungs better than Men's

NCT ID NCT06498505

Disease control Sponsor: University of Zurich Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether the drug acetazolamide (commonly used for altitude sickness) reduces pressure in the lung arteries differently in women compared to men when traveling to 3,600 meters. Over 300 healthy, non-smoking adults took either the drug or a placebo starting 24 hours before ascent. Researchers measured changes in heart and lung function using ultrasound to see if sex influences the drug's effect.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
acetazolamide
What this could lead to
If successful, this could show that acetazolamide helps prevent high-altitude pulmonary hypertension, especially in women.
What could go wrong
This is a completed Phase 4 trial in healthy volunteers, not patients. The effect may be small or not apply to people with existing health conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

303 people

The number who actually took part.

Started

Jul 2024

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 44 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy, non-smoking men and women, age 18-44 years, without any diseases and need of regular medication (including oral contraceptives). * BMI \>18 kg/m2 and \<30 kg/m2 * Born, raised and currently living at altitudes \<1000 m * Written informed consent * Premenopausal women with an eumenorrheic cycle Exclusion Criteria: * Other types of contraceptvies (hormonal intrauterine device, vaginal ring, subcutaneous injections or implants, among others) * Pregnancy or nursing * Anaemic (haemoglobin concentration \<10g/dl) * Any altitude trip \<4 weks before the study * Allergy to acetazolamide and other sulfonamides

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Conditions

The condition(s) this trial relates to.

altitude sickness Hypoxia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

High altitude

Contacts and locations

Locations

  • National Center for Cardiology and Internal Medicine

    Bishkek, Bishkek, 720040, Kyrgyzstan

More trials for these conditions

Other studies related to the condition(s) this trial covers.