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New MS drug candidate ABP 692 faces off against ocrevus in major trial

NCT ID NCT06700343

Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 28, 2026 · Updated 2 times

Summary

This study tests whether a new drug, ABP 692, works as well as the approved drug Ocrevus for people with relapsing-remitting multiple sclerosis (RRMS). About 152 adults with RRMS will receive either ABP 692 or Ocrevus to compare how the drugs move through the body and how well they reduce new brain lesions seen on MRI. The goal is to see if ABP 692 can be a similar, safe option for controlling MS.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

152 people

The number who actually took part.

Started

Jan 2025

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 99 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Diagnosis of RRMS in accordance with the revised McDonald Criteria 2017 (Thompson et al, 2018). 2. Expanded Disability Status Scale score at screening ≥ 0 and ≤ 5.5 inclusive. 3. Evidence of recent MS activity as defined by the study protocol. 4. Neurologically stable subject, with no relapse for ≤ 28 days before randomization. Exclusion Criteria: 1. Diagnosis of primary progressive or with secondary progressive MS (Thompson et al, 2018). 2. Multiple sclerosis disease duration of ≥ 10 years in Participants with Expanded Disability Status Scale (EDSS) score of ≤ 2.5 at screening. 3. Any contraindications to study procedures or medications as outlined in the study protocol. 4. Any prohibited medication as defined in the study protocol. 5. Any significant concomitant disease that may require chronic treatment with systemic corticosteroids and/or systemic immunosuppressants during the study. 6. Current or history of any significant medical conditions as described in the study protocol. 7. Any abnormal laboratory blood values as defined in the study protocol.

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Conditions

The condition(s) this trial relates to.

relapsing-remitting multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Relapsing-remitting multiple sclerosis (RRMS)

Contacts and locations

Locations

  • ARENSIA Clinics

    Bucharest, 011658, Romania

  • ARENSIA Exploratory Medicine at County Hospital Cluj-Napoca

    Cluj-Napoca, 400006, Romania

  • Aarhus Universitetshospital, Skejby

    Aarhus N, Central Jutland, 8200, Denmark

  • Academic Specialist Center

    Stockholm, SE113 65, Sweden

  • Advanced Neurosciences Research, Llc

    Fort Collins, Colorado, 80528, United States

  • Algemeen Ziekenhuis Delta

    Roeselare, West-Vlaanderen, 8800, Belgium

  • Aqualane Clinical Research

    Naples, Florida, 34105, United States

  • Arencia Exploratory Medicine

    Kyiv, 01135, Ukraine

  • Bellaria-Maggiore Hospital-Azienda USL Bologna

    Bologna, 40139, Italy

  • Casa di Cura Privata del Policlinico Igea S.p.A

    Milan, 20144, Italy

  • Centre Hospitalier Universitaire de Nimes (CHU) - Hopital Universitaire Caremeau

    Nîmes, 30029, France

  • Centrum Medyczne Neuroprotect

    Warsaw, 01-684, Poland

  • Centrum Neurologii Krzysztof Selmaj

    Lodz, 90-324, Poland

  • Clinic of Neurology, University Clinical Center Nis

    Niš, 18000, Serbia

  • Clinical Endpoints, LLC

    Scottsdale, Arizona, 85258, United States

  • Clinical Hospital Center Zvezdara

    Belgrade, 11000, Serbia

  • Curiositas-ad-Sanum GmbH

    Ebersberg, 85560, Germany

  • Dansk Multipel Sklerose Center

    Glostrup Municipality, 2600, Denmark

  • Diagnostic Consultative Center Convex Ltd

    Sofia, Sofiiska, 1680, Bulgaria

  • Emerald Coast Neurology/Synergy Clinical Research

    Pensacola, Florida, 32504, United States

  • Fakultna Nemocnica Trnava

    Trnava, 91775, Slovakia

  • Fakultni Nemocnice Hradec Kralove

    Hradec Králové, 500 05, Czechia

  • Fakultni nemocnice u sv. Anny v Brne

    Brno, 656 91, Czechia

  • Foothills Medical Centre

    Calgary, Alberta, T2N 2T9, Canada

  • Froedtert Hospital-Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Hackensack Meridian Health

    Paramus, New Jersey, 07652, United States

  • Hasbani Neurology

    New Haven, Connecticut, 06511, United States

  • Hawaii Pacific Neuroscience

    Honolulu, Hawaii, 96817, United States

  • Henry Ford Health

    Detroit, Michigan, 48202, United States

  • Hope Neurology

    Knoxville, Tennessee, 37922, United States

  • Hospital Alvaro Cunqueiro

    Vigo, 36312, Spain

  • Hospital Clinic de Barcelona - Institut Clinic de Malalties Hematologiques i Oncologiques (ICMHO)

    Barcelona, 08036, Spain

  • Hospital General Universitario Gregorio Maranon (HGUGM)

    Madrid, 28007, Spain

  • Hospital Regional Universitario de Malaga

    Málaga, 29010, Spain

  • Hospital Santa Caterina

    Salt, 17190, Spain

  • Hospital Universitario Doctor Peset

    Valencia, 46017, Spain

  • Hospital Universitario Fundacion Alcorcon

    Alcorcón, 28922, Spain

  • Hospital Universitario de Torrejon

    Torrejón de Ardoz, 28850, Spain

  • Hospital Vithas Nisa Sevilla

    Castilleja de la Cuesta, 41950, Spain

  • Hospital de Denia Marina Salud

    Dénia, 03700, Spain

  • Hospital of Lithuanian University of Health Sciences Kaunas

    Kaunas, 50161, Lithuania

  • JFK Medical Center

    Edison, New Jersey, 08820, United States

  • Jo Ann University Hospital

    Tbilisi, 0159, Georgia

  • Klaipedas University Hospital

    Klaipėda, LT-92288, Lithuania

  • Klinische Forschung Hamburg GmbH

    Hamburg, 20253, Germany

  • Knight Neurology

    Rockledge, Florida, 32955, United States

  • Krakowska Akademia Neurologii

    Krakow, 31-505, Poland

  • LTD Pineo Medical Ecosystem

    Tbilisi, 0114, Georgia

  • Lone Star Neurology

    Frisco, Texas, 75035, United States

  • MA-LEK Clinical Sp. z o.o.

    Katowice, Silesian Voivodeship, 40-571, Poland

  • MS Center Research Unit, Sahlgrenska University Hospital

    Gothenburg, 413 45, Sweden

  • MS-Netwerk Limburg - Revalidatie & MS Centrum

    Overpelt, 3900, Belgium

  • MTZ Clinical Research Powered by Pratia

    Warsaw, 02-172, Poland

  • Medical Center Hera EOOD

    Sofia, 1510, Bulgaria

  • Michigan Institute For Neurological Disorders (Glendale Neurological Associates) - Farmington Hills

    Farmington, Michigan, 48334-2979, United States

  • Mountain Neurological Research Center

    Basalt, Colorado, 81621, United States

  • Multipel Studies Institut fuer klinische Studien GbR

    Hamburg, 22179, Germany

  • NDx Clinical Research, Inc

    Dayton, Ohio, 45459, United States

  • NZOZ Neuromed M. i M. Nastaj Sp.P

    Lublin, 20-064, Poland

  • Nemocnica Ruzinov-Univerzitna Nemocnica Bratislava (UNB)

    Bratislava, 82626, Slovakia

  • Nemocnice Teplice

    Teplice, 415 01, Czechia

  • Neuro Medic Clinic

    Katowice, 40-686, Poland

  • Neuro-Care

    Katowice, Silesian Voivodeship, 40-749, Poland

  • Neurocentrum Bydgoszcz

    Bydgoszcz, 85-796, Poland

  • Neurologicka ambulancia Empathy, s.r.o.

    Bratislava, 85101, Slovakia

  • Neurology Offices of South Florida

    Boca Raton, Florida, 33428, United States

  • Neuropraxis Munchen Sud - Unterhaching

    Unterhaching, 82008, Germany

  • Nzoz Neuro-Kard Ilkowski I Partnerzy Spolka Partnerska Lekarzy

    Poznan, 61-853, Poland

  • Ondokuz Mayis University Health Practice and Research Hospital

    Samsun, 55280, Turkey (Türkiye)

  • Ospedale Regionale di Lugano, Sede Civico

    Lugano, 6903, Switzerland

  • Ospedale Sant'Andrea Hospital

    Rome, 00189, Italy

  • Praxisgemeinschaft fuer Neurologie, Psychiatrie und Psychotherapie - Regensburg

    Regensburg, 93059, Germany

  • Premier Neurology, PC

    Greenville, South Carolina, 29650, United States

  • Premiere Research Institute Palm Beach

    West Palm Beach, Florida, 33407, United States

  • Privatni ordinace neurologie

    Hradec Králové, 50003, Czechia

  • Profound Research - Neurology Center of Southern California

    Carlsbad, California, 92011, United States

  • Regional Hospital Jihlava

    Jihlava, 58601, Czechia

  • Resmedica Sp. z o.o.

    Kielce, 25-726, Poland

  • Rush University Medical Center, Rush University Cancer Center

    Chicago, Illinois, 60612-3841, United States

  • Sestre milosrdnice University Hospital Center

    Zagreb, 10000, Croatia

  • Singlepoint Healthcare Opco, LLC

    Columbus, Ohio, 43235, United States

  • Studienzentrum Dr. Bischof GmbH

    Böblingen, 71034, Germany

  • Sydvestjysk Sygehus

    Esbjerg, Region Syddanmark, 6700, Denmark

  • The Ottawa Hospital Research Institute

    Ottawa, Ontario, K1H 8L6, Canada

  • Triad Neurological Associates

    Winston-Salem, North Carolina, 27103, United States

  • UMHAT Dr.Georgi Stranski EAD

    Pleven, 5800, Bulgaria

  • UMHATEM N.I. Pirogov

    Sofia, 1606, Bulgaria

  • Uludag University Medical Faculty

    Bursa, 16059, Turkey (Türkiye)

  • Universidad de Sevilla - Hospital Universitario Virgen Macarena

    Seville, 41009, Spain

  • Universita degli Studi della Campania Luigi Vanvitelli - Clinica Neurologia II - Centro Sclerosi Mul

    Naples, 80138, Italy

  • Universitaetsklinikum Essen

    Essen, 45147, Germany

  • Universitaetsklinikum Heidelberg

    Heidelberg, 69120, Germany

  • Universitaetsklinikum Leipzig

    Leipzig, 04103, Germany

  • Universitaetsspital Bern - Inselspital

    Bern, 3010, Switzerland

  • Universitat de Valencia - Hospital Universitari i Politecnic La Fe de Valencia (Hospital La Fe Bulev

    Valencia, 46026, Spain

  • University Clinical Centre of Kragujevac

    Kragujevac, 34000, Serbia

  • University Hospital Carl Gustav Carus

    Dresden, 01307, Germany

  • University Hospital Centre Zagreb

    Zagreb, 10000, Croatia

  • University Medical Centre Ljubljana-UKCL

    Ljubljana, 1110, Slovenia

  • University Multi-Profile Hospital for Active Treatment (UMHAT) St. Ivan Rilski

    Sofia, 1431, Bulgaria

  • University of Kansas Medical Center

    Kansas City, Kansas, 66160, United States

  • University of NM/Mind Imaging center

    Albuquerque, New Mexico, 87131, United States

  • University of South Alabama

    Mobile, Alabama, 36617, United States

  • Vanderbilt University Medical Center (VUMC)

    Nashville, Tennessee, 37215, United States

  • Vitamed Galaj i Cichomski sp.j.

    Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-079, Poland

  • Vithas Hospital Parque San Antonio

    Malag, 29016, Spain

  • Yeditepe University Kosuyolu Hospital

    Kadıköy, Istanbul, 34718, Turkey (Türkiye)

  • ZNS Siegen GmbH

    Siegen, 57076, Germany

  • Zentrum fur klinische Forschung Dr.Scholl

    Bad Homburg, 61348, Germany

More trials for these conditions

Other studies related to the condition(s) this trial covers.