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Scientists probe body fluids to unravel deadly gut infection

NCT ID NCT04427891

Knowledge-focused Sponsor: Sahlgrenska University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at 50 patients with peritonitis caused by a burst diverticulum in the colon. Researchers will measure 92 inflammatory proteins in abdominal fluid and blood, and analyze tissue and bacteria changes. The goal is to better understand why some people develop this life-threatening infection, not to test a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help doctors better understand why diverticulitis leads to life-threatening peritonitis, potentially pointing toward new ways to predict or treat it.
What could go wrong
This is a small, early descriptive study with no treatment being tested. It only looks at biological changes, so it won't directly lead to a new therapy. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2021

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The aim is to study immune responses in patients with perforated divrticulitis leading to peritonitis and emergency surgery. This group will be compared with patients operated for colorectal cancer and patients with uncomplicated (mild) diverticulitis not undergoing surgery.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Signs of perforated diverticulitis with peritonitis and decision to perform emergency surgery (Group I) * Signs of acute diverticulitis and no decision of emergency surgery (Group II) * Patients with colorectal cancer planned for elective surgery (Group III) Exclusion Criteria: * No surgery performed (Group I and III) * Withdrawn consent (any group)

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Conditions

The condition(s) this trial relates to.

diverticulitis diverticulitis of colon peritonitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Perforated diverticulitis

Contacts and locations

Locations

  • Sahlgrenska University Hospital/Östra

    Gothenburg, Västra Götaland County, SE 416 85, Sweden

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