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New drug combo aims to fight aggressive lung cancer

NCT ID NCT07155174

Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Sep 11, 2026 · Updated 21 times

Summary

This study tests a new drug called ABBV-706 combined with the immunotherapy atezolizumab as a first treatment for people with extensive-stage small cell lung cancer, a fast-growing cancer that has spread. About 180 adults will receive either the new combination at one of two doses or standard chemotherapy plus immunotherapy. Researchers will check safety and how long the cancer stays under control.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ABBV-706 (an investigational drug) combined with atezolizumab (an immunotherapy)
What this could lead to
If successful, this could offer a new first-line treatment option for extensive-stage small cell lung cancer, potentially improving how long patients live without their cancer growing.
What could go wrong
This is an early Phase 2 study with only 180 participants, so results may not apply to everyone. The new combination may cause more side effects than standard care, and it is not yet proven to be better.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 180 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Sep 2031

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of histologically or cytologically confirmed extensive stage small cell lung cancer (ES-SCLC) requiring treatment with first line therapy. * Have an Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 to 1 during the screening period prior to the first dose of study treatment. * Have measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST v1.1). * Suspected brain metastases at screening should have a computed tomography (CT)/ magnetic resonance imaging (MRI) of the brain prior to study entry. Exclusion Criteria: * Have received any kind of treatment for limited stage small cell lung cancer (LS-SCLC). * Known active/symptomatic central nervous system (CNS) metastases should be excluded. * History of interstitial lung disease (ILD) or pneumonitis that required treatment with systemic steroids, or any evidence of active ILD/pneumonitis on screening chest computed tomography (CT) scan should be excluded. * Have any clinically significant conditions that would adversely affect the participant's participation in the study, and the subject should have a life expectancy of at least 3 months.

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Conditions

The condition(s) this trial relates to.

small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Small cell lung cancer

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    67 sites in 13 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • AZ Maria Middelares /ID# 277027

    RECRUITING

    Ghent, Oost-Vlaanderen, 9000, Belgium

  • Adana Sehir Hastanesi /ID# 277082

    RECRUITING

    Adana, 01370, Turkey (Türkiye)

  • Ankara Universitesi Tip Fakultesi Cebeci Hastanesi /ID# 277076

    RECRUITING

    Ankara, 06620, Turkey (Türkiye)

  • Asan Medical Center /ID# 277603

    RECRUITING

    Seoul, Seoul Teugbyeolsi, 05505, South Korea

  • Assuta Ashdod Medical Center /ID# 276661

    RECRUITING

    Ashdod, Southern District, 7747600, Israel

  • Baptist Health Lexington /ID# 277729

    RECRUITING

    Lexington, Kentucky, 40503, United States

  • Cancer Hospital - Chinese Academy of Medical Sciences /ID# 277167

    RECRUITING

    Beijing, Beijing Municipality, 100021, China

  • Chung Shan Medical University Hospital /ID# 277660

    RECRUITING

    Taichung, 402, Taiwan

  • Chungbuk National University Hospital /ID# 277429

    RECRUITING

    Cheongju-si, North Chungcheong, 28644, South Korea

  • Clinical Hospital Center - Bezanijska Kosa /ID# 277013

    RECRUITING

    Belgrade, Beograd, 11080, Serbia

  • Complejo Hospitalario Universitario A Coruna /ID# 276922

    RECRUITING

    A Coruña, 15006, Spain

  • Dana-Farber Cancer Institute /ID# 277732

    RECRUITING

    Boston, Massachusetts, 02215, United States

  • Evangelische Lungenklinik Berlin /ID# 277094

    RECRUITING

    Berlin, 13125, Germany

  • Fondazione Policlinico Universitario Campus Bio-Medico /ID# 277744

    RECRUITING

    Roma, 00128, Italy

  • Fort Wayne Medical Oncology And Hematology /ID# 277336

    RECRUITING

    Fort Wayne, Indiana, 46804, United States

  • Gazi University Medical Faculty /ID# 276843

    RECRUITING

    Ankara, 06560, Turkey (Türkiye)

  • Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi /ID# 276839

    RECRUITING

    Istanbul, 34722, Turkey (Türkiye)

  • Grand Hopital de Charleroi - Les Viviers /ID# 276897

    RECRUITING

    Charleroi, Hainaut, 6280, Belgium

  • Groupe Sante CHC - Clinique du MontLegia /ID# 276783

    RECRUITING

    Liège, Liege, 4000, Belgium

  • Hadassah Medical Center-Hebrew University /ID# 276662

    RECRUITING

    Jerusalem, 91120, Israel

  • Henan Cancer Hospital /ID# 277059

    RECRUITING

    Zhengzhou, Henan, 450008, China

  • Hospital Clinic de Barcelona /ID# 276878

    RECRUITING

    Barcelona, 08036, Spain

  • Hospital General Universitario Gregorio Maranon /ID# 276877

    RECRUITING

    Madrid, 28007, Spain

  • Hospital Regional Universitario de Malaga /ID# 276927

    RECRUITING

    Málaga, Andalusia, 29010, Spain

  • Hospital Universitario 12 de Octubre /ID# 277251

    RECRUITING

    Madrid, 28041, Spain

  • IRCCS Istituti Fisioterapici Ospitalieri-Istituto Nazionale Tumori Regina Elena /ID# 276792

    RECRUITING

    Rome, Roma, 00144, Italy

  • Institute For Pulmonary Diseases Of Vojvodina /ID# 277003

    RECRUITING

    Kamenitz, Sremski Okrug, 21208, Serbia

  • Jessa Ziekenhuis - Campus Virga Jesse /ID# 276781

    RECRUITING

    Hasselt, Limburg, 3500, Belgium

  • Kaohsiung Chang Gung Memorial Hospital /ID# 277725

    RECRUITING

    Kaohsiung City, 833, Taiwan

  • Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 277267

    RECRUITING

    Kaohsiung City, 807, Taiwan

  • Linkou Chang Gung Memorial Hospital /ID# 277264

    RECRUITING

    Taoyuan City, 333, Taiwan

  • Liv Hospital Ankara /ID# 276842

    RECRUITING

    Ankara, 06680, Turkey (Türkiye)

  • Lungenfachklinik Immenhausen /ID# 278005

    RECRUITING

    Immenhausen, Hesse, 34376, Germany

  • Meir Medical Center /ID# 277292

    RECRUITING

    Kefar Sava, Central District, 4428164, Israel

  • Memorial Ankara Hastanesi /ID# 276840

    RECRUITING

    Ankara, 06520, Turkey (Türkiye)

  • Missouri Cancer Associates /ID# 278299

    RECRUITING

    Columbia, Missouri, 65201, United States

  • Moffitt Cancer Center /ID# 277573

    RECRUITING

    Tampa, Florida, 33612, United States

  • Narodowy Instytut Onkologii Im. Marii Sklodowskiej-Curie Panstwowy Instytut Bada /ID# 277112

    RECRUITING

    Warsaw, Masovian Voivodeship, 02-781, Poland

  • National Cancer Center /ID# 277434

    RECRUITING

    Goyang-si, Gyeonggido, 10408, South Korea

  • National Cancer Center Hospital /ID# 277237

    RECRUITING

    Chuo-Ku, Tokyo, 104-0045, Japan

  • National Cancer Center Hospital East /ID# 277239

    RECRUITING

    Kashiwa-shi, Chiba, 277-8577, Japan

  • Ocala Oncology Center /ID# 278269

    RECRUITING

    Ocala, Florida, 34474, United States

  • Rambam Health Care Campus- Haifa /ID# 276663

    RECRUITING

    Haifa, 3109601, Israel

  • Samsung Medical Center /ID# 277615

    RECRUITING

    Seoul, Seoul Teugbyeolsi, 06351, South Korea

  • Seoul National University Hospital /ID# 277271

    RECRUITING

    Seoul, Seoul Teugbyeolsi, 03080, South Korea

  • Shanghai East Hospital /ID# 277111

    RECRUITING

    Shanghai, Shanghai Municipality, 200120, China

  • Shanghai Pulmonary Hospital /ID# 276960

    RECRUITING

    Shanghai, Shanghai Municipality, 200433, China

  • Shizuoka Cancer Center /ID# 277243

    RECRUITING

    Sunto-gun, Shizuoka, 411-8777, Japan

  • Taipei Veterans General Hospital /ID# 277263

    RECRUITING

    Taipei, 112, Taiwan

  • The Chaim Sheba Medical Center /ID# 276660

    RECRUITING

    Ramat Gan, Tel Aviv, 5265601, Israel

  • The First affiliated hospital of Nanchang University /ID# 277247

    RECRUITING

    Nanchang, Jiangxi, 330006, China

  • The University of Texas MD Anderson Cancer Center /ID# 277929

    RECRUITING

    Houston, Texas, 77030, United States

  • Tokyo Metropolitan Komagome Hospital /ID# 277335

    RECRUITING

    Bunkyo Ku, Tokyo, 113-8677, Japan

  • Union Hospital Tongji Medical College /ID# 277912

    RECRUITING

    Wuhan, Hubei, 430048, China

  • Universitaetsklinikum Giessen und Marburg GmbH /ID# 277466

    RECRUITING

    Marburg, Hesse, 35043, Germany

  • University Clinical Center Kragujevac /ID# 277179

    RECRUITING

    Kragujevac, Sumadijski Okrug, 34000, Serbia

  • University Clinical Center Nis /ID# 277180

    RECRUITING

    Niš, Nisavski Okrug, 18300, Serbia

  • University Clinical Center Serbia /ID# 277007

    RECRUITING

    Belgrade, Beograd, 11000, Serbia

  • University Hospitals Cleveland Medical Center /ID# 277556

    RECRUITING

    Cleveland, Ohio, 44106, United States

  • University of Florida College of Medicine /ID# 277496

    RECRUITING

    Gainesville, Florida, 32610, United States

  • Uniwersytecki Szpital Kliniczny Nr 4 w Lublinie /ID# 276910

    RECRUITING

    Lublin, Lublin Voivodeship, 20-090, Poland

  • Virginia Cancer Specialists - Fairfax /ID# 278298

    RECRUITING

    Fairfax, Virginia, 22031, United States

  • Wakayama Medical University Hospital /ID# 277260

    RECRUITING

    Wakayama, Wakayama, 641-8510, Japan

  • West China Hospital of Sichuan University /ID# 277852

    RECRUITING

    Chengdu, Sichuan, 610041, China

  • Wielkopolskie Centrum Pulmonologii i Torakochirurgii im. Eugenii i Janusza Zeyla /ID# 276907

    RECRUITING

    Poznan, Greater Poland Voivodeship, 60-569, Poland

  • Yale University School of Medicine /ID# 278181

    RECRUITING

    New Haven, Connecticut, 06510, United States

  • Yonsei University Health System Severance Hospital /ID# 277597

    RECRUITING

    Seoul, Seoul Teugbyeolsi, 03722, South Korea

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