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Cash for quitting: study tests if a month without weed boosts HIV health

NCT ID NCT04866004

Disease control Sponsor: The University of Texas Health Science Center at San Antonio Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looked at whether people with HIV who regularly use cannabis could stop for 28 days and whether that would improve their mood, pain, sleep, and HIV viral load. Twenty-five participants were given financial incentives to stay cannabis-free, with urine tests to confirm. The goal was to see if this approach is feasible and if it reduces inflammation and distress.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
contingency management (financial incentives for cannabis abstinence)
What this could lead to
If successful, this could show that stopping cannabis use for a month helps people with HIV feel less distressed and may improve their HIV control.
What could go wrong
This is a very small pilot study with only 25 participants and no comparison group, so results may not apply broadly. It only tests short-term abstinence, not long-term effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

25 people

The number who actually took part.

Started

Aug 2021

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * HIV-positive (confirmed via HIV medication or relevant HIV labs in subject's name) * Self-report of cannabis use at least once per week in the 6-month period prior to consent * Provide a positive urine toxicology (UTOX) screen for cannabis * Not seeking treatment for cannabis use * Willing to stop using cannabis for 28 days and attend eight study visits over six weeks. * Ability and willingness to provide inform consent * English fluency Exclusion Criteria: * Currently receiving treatment for cannabis or other drug use disorder * Diagnosed or receiving treatment for a current major depressive or anxiety disorder * Diagnosed with any current alcohol or substance use disorder (excluding nicotine) using the Structured Clinical Interview for Clinical Disorders (SCID) Interview (22) * Positive UTOX screen for opioids * Having a medical, psychiatric, occupational, or other condition that, in the judgment of the study physician, would make participation difficult or unsafe.

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Conditions

The condition(s) this trial relates to.

cannabis dependence HIV infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV infections Marijuana

Contacts and locations

Locations

  • Center for Neurobehavioral Research on Addiction

    Houston, Texas, 77054, United States

  • University of Texas Health Science Center at San Antonio

    San Antonio, Texas, 78229, United States

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