New scan could spot hidden prostate cancer

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* INCLUSION CRITERIA: * Age greater than or equal to 18 years old. * Eastern Cooperative Oncology Group (ECOG) Performance score of 0 to 2. * Ability of subject to understand and the willingness to sign a written informed consent document. * Histologically confirmed adenocarcinoma of the prostate. * Patients (including those receiving androgen deprivation therapy) fit criteria for one of the following categories: * Cohort 1 known localized high risk prostate cancer (PSA \>10, Gleason 8-10 or clinical stage \>T2c) with evidence of disease on standard imaging, OR * Cohort 2 nonspecific or no evidence of disease on standard imaging modality AND biochemical prostate cancer relapse with a PSA greater than or equal to 0.2 ng/mL. Patients must be willing to undergo mandatory research biopsy * Participants must be co-enrolled on a MIB, UOB, GMB or ROB protocol. * The effects of 18F-DCFPyL on the developing human fetus are unknown. For this reason, individuals must agree to use adequate contraception with their partner (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation and 2 months after 18F-DCFPyL scan. Should a partner become pregnant or suspect she is pregnant while her partner is participating in this study, she should inform the treating physician immediately. EXCLUSION CRITERIA: * Subjects for whom participating would significantly delay the scheduled standard of care therapy. * Subjects with any coexisting medical or psychiatric condition that is likely to interfere with study procedures and/or results. * Subjects with severe claustrophobia unresponsive to oral anxiolytics * Other medical conditions deemed by the principal investigator (or associates) to make the subject unsafe/ineligible for protocol procedures. * Subjects weighing greater than 350 lbs. (weight limit for scanner table), or unable to fit within the imaging gantry. * Serum creatinine greater than 2 times the upper limit of normal.