University Of Southern California

This study is testing if adding an experimental immune-stimulating drug (PF-04518600) to a standard cancer drug (axitinib) works better for controlling advanced kidney cancer that has spread. The trial involves 62 patients whose cancer worsened after prior immunotherapy. Particip…

This small pilot study explores whether surgery can be performed safely after chemotherapy in patients with advanced pancreatic cancer that was previously considered inoperable. Researchers want to see if this combined approach can completely remove tumors that have grown near ma…

This study is testing whether eating a special, low-calorie diet before and during chemotherapy can help reduce side effects and make the treatment work better. It involves 130 people with breast cancer or prostate cancer who are receiving specific chemotherapy drugs. Participant…

This study aimed to compare four different surgical techniques for treating receding gums (gingival recession). It planned to enroll 100 adults with multiple areas of gum recession to see which method best covered exposed tooth roots. The study was withdrawn before any participan…

This early-stage study is testing a combination of two drugs, guadecitabine and durvalumab, in people with advanced cancers of the liver, pancreas, bile duct, or gallbladder that have spread. The main goals are to find the safest dose and see what side effects occur. Researchers …

This early-phase study is testing a personalized cell therapy for advanced triple-negative breast cancer that has returned or stopped responding to standard treatments. Doctors take a patient's own immune cells, modify them in a lab to recognize cancer, and infuse them back to at…

This small, early-stage study is testing whether short-term fasting before standard immunotherapy is safe and practical for people with advanced skin cancer. Researchers want to see if patients can follow the fasting schedule and if it causes serious side effects. The hope is tha…

This study is testing whether giving an immunotherapy drug called cemiplimab before surgery helps treat a type of skin cancer called cutaneous squamous cell carcinoma. The drug aims to help the patient's own immune system attack the cancer and shrink the tumor, potentially making…

This study is testing whether a lung cancer immunotherapy drug can be safely and effectively given at home by a visiting nurse, with most doctor visits done remotely via video call. It involves patients with non-small cell lung cancer who are eligible for the drug atezolizumab. T…

This early-stage trial is testing the safety of a new combination treatment for people with advanced cancers that have spread and cannot be removed by surgery. Doctors inject immune-stimulating drugs directly into a tumor, then give a small dose of radiation to that same spot. Th…

This small pilot study aimed to test if a special vacuum bandage system helps surgical wounds heal better after a leg amputation, compared to standard bandage care. The plan was to enroll 6-10 people who had an amputation and randomly assign them to either the new vacuum therapy …

This study compares two physical therapy programs for infants and toddlers (8-24 months old) with or at high risk for cerebral palsy. One program (START-Play) focuses on sitting, reaching, and problem-solving during play. The other is a standard physical therapy approach. The goa…

This study is testing if adding a patient's own concentrated platelets (platelet-rich plasma or PRP) to the surgical mesh used in hiatal hernia repair can make the repair stronger and last longer. It will compare the standard mesh repair to the same repair enhanced with PRP in 15…

This study is testing a new drug called pevonedistat, given alongside standard chemotherapy drugs, for adults newly diagnosed with high-risk acute myeloid leukemia (AML). The main goals are to find the safest and most effective dose of the new combination and to see if it helps m…

This early-stage study is testing the safety and best dose of a new drug called sEphB4-HSA when given alongside standard chemotherapy. It involves about 61 people with specific advanced or spreading cancers, including pancreatic, lung, and head/neck cancers, that have stopped res…

This study is for men with advanced prostate cancer that has stopped responding to standard hormone therapy and has spread to the bones. It aims to see if adding a targeted radiation drug (Radium223) to a standard cancer-fighting pill (enzalutamide) works better than the pill alo…

This study is testing a new combination of two drugs, guadecitabine and atezolizumab, for adults with advanced myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML). It is for patients whose cancer has returned or stopped responding to standard treatments. The …

This study is testing whether an oral antibiotic called linezolid can effectively treat early syphilis. It aims to provide an alternative to the standard penicillin shot, which can be hard to get or administer. The trial involves 24 adults with early syphilis, including some with…

This study is testing whether adding a modified virus (pelareorep) to a combination of standard chemotherapy and immunotherapy drugs is safe and more effective for people with multiple myeloma that has come back or stopped responding to treatment. The goal is to see if the virus …

This study is testing a new blood and urine test to see if it can help doctors find kidney cancer early and track how it responds to treatment. Researchers are comparing results from healthy volunteers, patients with localized cancer having surgery, and patients with advanced can…

This study aims to see how well a specific blood marker (called miRNA-371) can predict if testicular cancer is active and has spread to nearby lymph nodes. Researchers will collect blood samples from about 418 patients with suspected cancer spread and compare the test results to …

This study compares two methods for finding serious prostate cancer in men with elevated PSA levels. Researchers want to see if using MRI scans to guide biopsies works better than the standard random biopsy approach. The study specifically includes both African American and white…

This study tests whether screening caregivers for risk factors and providing them with support sessions can help prevent elder mistreatment of people with dementia. Researchers will compare different groups of caregivers to see if these approaches reduce stress, depression, and b…

This small pilot study is testing whether it's practical to compare two common methods for closing surgical wounds after bone fracture repair: traditional stitches (sutures) versus metal staples. Researchers want to see if they can successfully recruit patients and collect data t…

This study is testing whether using virtual reality (VR) goggles during painful procedures can help reduce pain and anxiety for cancer patients. Hospitalized patients undergoing a bone marrow biopsy or spinal tap will be randomly assigned to either use VR during the procedure or …

This study tests whether monthly group meals with guided conversation can reduce burnout and loneliness in medical students during their clinical training years. Researchers will form small groups of 6-8 students with a resident leader who meet for six months. The goal is to see …

This study compares two established online group talk therapies for major depression: Cognitive Behavioral Therapy (CBT) and Acceptance and Commitment Therapy (ACT). Up to 100 adults in California will be randomly assigned to receive 8 weeks of one therapy via Zoom, followed by 6…

This study is testing whether adding a simple surgical step called vesicopexy during robot-assisted prostate cancer surgery helps men regain bladder control faster. Researchers will compare two groups of men: one receiving the standard surgery and one receiving the surgery with t…

This study is testing a new, combined approach to help people walk better after a stroke. It merges two established therapies: one that uses real-time feedback to correct walking form and another that focuses on building walking endurance. The goal is to see if this combined meth…

This study is testing a new bilingual web application designed to help people with chronic sinusitis make more informed decisions about their treatment, specifically whether to have surgery. The tool provides educational resources and stories from other patients to support shared…

This study is testing whether a liquid medicine containing THC and CBD (compounds from cannabis) can reduce agitation and distress in people with advanced dementia who are eligible for hospice care. About 120 participants will take either the active medicine or a placebo for 12 w…

This study aims to see if a very powerful type of MRI scanner can provide clearer pictures of the brain in men who have had testicular cancer and now have low testosterone. Researchers want to observe if there are any brain structure changes over a year in 10 men who are already …

This study aims to find out if two years of after-school music training improves brain development in children. Researchers will compare 114 children aged 6-8 who either take music lessons or participate in other arts activities. They will use brain scans and behavior tests to se…

This study aims to understand how colorectal cancer affects the physical health and emotional well-being of young adults (ages 18-39). Researchers are observing patients during treatment and after completing therapy to measure symptoms, quality of life, and physical function. The…

This small pilot study aims to see if taking a daily Vitamin D supplement for three weeks changes testosterone levels in young, healthy women. Researchers will compare 20 participants, some taking Vitamin D and some taking a placebo pill, by measuring hormone levels in their bloo…

This study aims to better understand how Alzheimer's disease develops and progresses over time. It will follow 1,500 older adults, including those with normal memory, mild memory problems, and dementia, for up to five years. Researchers will use memory tests, brain scans, and blo…

This study is testing an educational program designed to train Hispanic/Latino community members as educators about colorectal cancer genetics. The goal is to increase knowledge about genetic testing and research in communities that are often underrepresented in these studies. Pa…

This study wanted to see if using the AI chatbot ChatGPT could help adults newly diagnosed with a benign ear tumor called vestibular schwannoma feel less conflicted and more satisfied with their treatment decisions. It planned to compare two groups: one trained to use ChatGPT for…