The Third Xiangya Hospital Of Central South University

This trial tests an experimental drug called SAL0195, given as a single injection under the skin, in about 40 adults aged 18 to 65. Some participants have elevated lipoprotein(a), a fatty particle in the blood linked to heart disease and stroke, while others do not. Researchers g…

This trial compares a single injection of HHK001, an improved version of the drug leuprorelin, with the standard Enantone injection in 20 women with endometriosis. Researchers measure how the drug moves through the body, its safety, and early signs of effectiveness. The goal is t…

This trial is testing an investigational drug called KL0011034, given by infusion, alongside the opioid alfentanil in people with moderate-to-severe chronic pain that is not caused by cancer. The study aims to see how the two drugs interact in the body, and whether the combinatio…

This trial tests a nurse-led program designed to help people with chronic heart failure better manage fluid buildup—a common cause of hospital readmission. The program includes education, emotional support, and practical skills like daily weighing and salt restriction. Researcher…

This Phase 2 trial tests whether adding two drugs (benmelstobart and anlotinib) to standard chemotherapy before chemoradiation helps people with stage III lung cancer that cannot be removed by surgery. 152 participants will be randomly assigned to receive either the new induction…

This study compares two glucose monitoring methods—continuous glucose monitors (CGM) and traditional finger-prick tests—in adults with type 2 diabetes who are taking the drug dapagliflozin. The 120 participants will be split into two groups and followed for 12 weeks to see which …

This study tests an oral traditional Chinese medicine made from the fungus C. cicadae in people with ALS who have high levels of certain fats (sphingolipids) in their blood. About 84 participants will receive either the medicine or a placebo for 6 months, with follow-up for 9 mon…

This study tests whether choosing blood pressure medication based on a person's specific heart and blood vessel measurements (hemodynamic phenotyping) works better than the usual guideline-based approach. About 240 adults with mild-to-moderate hypertension who have never taken bl…

This early-phase trial will test a new tumor vaccine (SapDM275) combined with standard chemotherapy in 13 people with metastatic pancreatic cancer who have not had prior treatment. The vaccine aims to help the immune system attack cancer cells. The main goal is to check safety, b…

Researchers are testing a new way to measure how much sweat the body produces during controlled heat exposure. About 20 healthy volunteers and up to 10 people with ROSAH syndrome, a rare genetic condition that can cause reduced sweating, will sit in a temperature-controlled sauna…

This trial tests whether a lifestyle program that includes the partner can help women who had gestational diabetes improve their weight and blood sugar control. Participants receive three months of health education on diet, physical activity, and stress management, with one group…

This Phase 1 trial in 21 healthy adults compares a new formulation of HBW-3220 capsules with the previous version. Each participant receives a single 120 mg dose under three conditions: old formulation fasting, new formulation fasting, and new formulation after a high-fat meal. R…

This Phase 1 trial in about 18 healthy adults tests whether taking NTQ5082 capsules changes how the body processes midazolam, a short-acting sedative used as a probe to measure liver enzyme activity. Participants receive midazolam alone and then alongside single and repeated dose…