Shanghai Public Health Clinical Center

This study tests whether adding a fluoroquinolone antibiotic (levofloxacin or moxifloxacin) to the usual three-drug treatment helps people with HIV who have a serious infection called disseminated MAC. About 124 adults will be randomly assigned to get either the standard triple t…

This study tests a drug called Sintilimab, which is normally used for cancer, to see if it can help people with HIV who have infections that won't go away with standard treatments. The drug works by waking up tired immune cells. About 50 adults will receive the drug alongside the…

This study tests whether a short course of the steroid prednisolone can prevent a serious condition called IRIS in people with AIDS who are starting HIV treatment. IRIS happens when the recovering immune system overreacts to hidden infections. The trial will enroll 262 participan…

This study will follow 8,000 people with HIV to see how well their antiviral therapy works when they also have other infections like tuberculosis or pneumonia. Researchers want to find the best treatment plans for these patients and build models to predict their outcomes. The goa…