Proton Collaborative Group

This study is for people with pancreatic cancer that cannot be surgically removed. It tests whether giving a higher dose of proton radiation along with the oral chemotherapy drug capecitabine can help more patients become eligible for surgery and improve survival. About 60 partic…

This study compares two treatments for men with intermediate-risk prostate cancer that hasn't spread: proton beam radiation alone versus radiation plus hormone-blocking therapy (androgen suppression). About 192 men will receive either 28 sessions of proton therapy or the same rad…

This study looks at how well proton radiation (and sometimes hormone therapy) works for prostate cancer that has come back or is at high risk of coming back after surgery. About 70 men whose cancer has not spread will receive this treatment. The goal is to control the cancer whil…

This study tests whether proton radiation, a precise type of radiation, can control early-stage breast cancer in women aged 50 and older. The goal is to see if targeting only the tumor area can prevent cancer from coming back while reducing side effects. About 132 women will rece…

This study tests if a shorter, 3-week course of proton radiation is as safe and effective as the standard 5-week course for women with breast cancer who need radiation to the breast or chest wall and nearby lymph nodes. About 276 participants will receive either the shorter or lo…

This study is collecting health information from up to 40,000 people receiving radiation therapy for cancer. The goal is to learn what works best and how to reduce side effects. No new treatments are being tested—just tracking real-world results to improve future care.