Pediatric Brain Tumor Consortium

This early-stage study tested a drug called APX005M in 32 children whose brain tumors had come back or were hard to treat, including a type called DIPG. The goal was to find a safe dose and see how the body reacts. The drug works by helping the immune system attack the tumor cell…

This study aimed to test an experimental virus therapy, G207, given directly into the brain tumor along with a single dose of radiation for children whose high-grade glioma had come back after standard treatment. The goal was to see if this combination could help children live lo…

This study tests a new treatment for children whose medulloblastoma or ependymoma has come back after standard therapy. It combines a radioactive antibody delivered directly into the brain fluid with standard chemotherapy drugs. The goal is to see if this approach can help contro…

This study tests whether adding hydroxychloroquine (a malaria drug) to targeted cancer drugs (dabrafenib and/or trametinib) can help children and young adults with certain brain tumors that have come back or not responded to previous treatment. Participants must have tumors with …