Ottawa Heart Institute Research Corporation

This study tests whether dapagliflozin, a drug used for diabetes, can improve quality of life in people with long COVID. About 192 adults with persistent symptoms after a COVID infection will receive either the drug or a placebo for 12 months. The main goal is to see if the drug …

This study tests whether giving heart stent patients anti-platelet drugs based on their genes can lower the risk of dangerous bleeding compared to the standard one-size-fits-all approach. About 1,760 adults who have had a stent placed will be randomly assigned to either the perso…

This study looks at whether making a small opening between the upper chambers of the heart during mitral valve surgery can help prevent heart failure symptoms after the operation. The trial will include 50 adults with severe mitral regurgitation (a leaky heart valve) who are sche…

This study tests if midodrine, a drug that raises blood pressure, can help people with heart failure and low blood pressure tolerate standard heart failure medications. About 56 adults with weak hearts and low blood pressure will be randomly assigned to get midodrine or usual car…

This pilot study checks if a larger trial is possible, comparing two methods of taking a chest artery for heart bypass surgery. About 35 adults having planned bypass surgery will join. The goal is to see which method leads to fewer infections and better long-term artery openness.

This study looks for clues—like blood tests and heart scans—to predict which patients will have repeated episodes of pericarditis (inflammation around the heart). About 44 adults with a history of recurrent pericarditis will undergo a special PET/CT scan and be followed over time…

This study looks at how menopause and poor sleep change heart structure and function in women aged 48-58 with type 2 diabetes. Researchers will use heart ultrasounds to measure early signs of heart strain. No treatment is given; the goal is to better understand these risks.