National Cancer Institute, Naples

This study is testing whether a drug called regorafenib works better than standard second-line treatments for people with advanced colorectal cancer that has a specific genetic change (RAS mutation). The trial will enroll 60 patients whose cancer progressed after initial treatmen…

This study is observing how well the immunotherapy drug dostarlimab works for patients with a specific type of advanced rectal cancer in real-world medical settings, not a controlled trial. It will follow about 50 patients in Italy who are already receiving this treatment to see …

This study is testing whether a combination of two existing drugs, pembrolizumab and lenvatinib, can help control advanced vulvar cancer. It will enroll 80 women whose cancer cannot be removed by surgery, has come back, or has spread. The main goals are to see if the treatment sh…

This study is testing if adding valproic acid, a drug used for epilepsy, to standard cancer drugs can better control advanced colorectal cancer that has returned after prior treatment. It will involve about 130 patients whose cancer has spread and who have already been treated wi…

This study is testing a new, more advanced robotic surgery system for treating early-stage endometrial (uterine) cancer. The goal is to perform the necessary cancer staging surgery through just one small abdominal incision instead of several. Researchers will enroll about 564 pat…

This study aims to collect and analyze information from 15,000 cancer patients in Italy's Campania region. It will look at how patients move through the healthcare system, what treatments they receive, and their outcomes. The goal is to understand current care patterns and find w…

This study aims to understand how the cost of breast cancer treatment affects patients' financial well-being over time. Researchers will follow 864 people with early-stage breast cancer for one year after they start treatment. The study will track financial stress, quality of lif…

This study aims to understand whether certain proteins called selenoproteins could serve as markers for breast cancer progression or as targets for future treatments. Researchers will analyze tissue samples from past patients and collect blood samples from 300 breast cancer patie…