Merck Sharp & Dohme

This trial tests whether the 9-valent HPV vaccine (V503) can trigger a strong immune response against nine HPV types in Chinese females aged 10 to 45 who previously received the bivalent (2-type) HPV vaccine. Participants will receive either the 9-valent vaccine or a placebo, and…

This trial is testing whether a targeted therapy called raludotatug deruxtecan (R-DXd), given alone or with bevacizumab, can help people with newly diagnosed advanced ovarian cancer live longer without their cancer growing. Participants have already completed first-line platinum-…

Researchers are testing whether adding sacituzumab tirumotecan and subcutaneous pembrolizumab to chemoradiotherapy helps people with muscle-invasive bladder cancer live longer without the cancer growing or returning. The trial enrolls about 400 people who have chosen bladder pres…

Researchers are testing an oral drug called enlicitide decanoate in adults with hyperlipidemia, a condition marked by high cholesterol. The phase 3 trial enrolls 150 people in India who have had a heart-related event or face high risk, and who still have elevated LDL cholesterol.…

This trial is testing whether a new drug called raludotatug deruxtecan (R-DXd), given alone or with bevacizumab, can help people with advanced ovarian cancer live longer and delay cancer growth compared to standard chemotherapy. The study includes adults with high-grade serous or…

This phase 2 trial tests the safety of belzutifan, a daily oral tablet, in adolescents with rare solid tumors that cannot be surgically removed or have spread. The study includes three tumor types: pheochromocytoma/paraganglioma (PPGL), wild-type gastrointestinal stromal tumors (…

This trial tests whether pembrolizumab, an immunotherapy drug, is safe when combined with chemotherapy or chemoradiotherapy for people in India with advanced gastric or gastroesophageal junction cancer, advanced biliary tract cancer, or high-risk locally advanced cervical cancer.…

This Phase 2 trial tests an investigational drug called MK-2010, which is designed to help the immune system attack cancer. Researchers will give MK-2010 alone or in combination with other treatments to about 480 people with advanced solid tumors, meaning cancers that have spread…

This early-stage trial is testing different pill versions of an experimental drug called MK-4082, which is being developed as a potential weight-loss treatment. The study will enroll about 48 healthy adults who are overweight or obese to see how well the body absorbs each version…

This phase 2 trial tests an experimental biologic called MK-1045 in people with relapsed or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The study aims to see if MK-1045 is safe and tolerable, and how many participants respond to treatment. P…

This phase 2 trial is testing whether combining an experimental immunotherapy (MK-2010) with an antibody-drug conjugate (sacituzumab tirumotecan) can help people with advanced solid tumors. The goal is to see if the combination is safe and can shrink or eliminate tumors. Particip…

This study tests the safety of a new medicine called sotatercept for adults in India with pulmonary arterial hypertension (PAH), a condition where blood vessels in the lungs become narrow, making breathing hard. About 30 people will receive sotatercept along with their usual trea…

This trial tests whether an experimental drug called bomedemstat can help people with polycythemia vera (a condition where the body makes too many red blood cells) who did not get better with or could not tolerate the common treatment hydroxyurea. Participants will receive either…

This phase 3 trial compares an experimental drug, MK-8748, to the standard treatment aflibercept for diabetic macular edema (DME), a condition where fluid buildup in the retina blurs vision. About 1,100 adults with diabetes and vision loss from DME receive either MK-8748 or aflib…

This early-stage trial is testing whether a single dose of an experimental HIV medicine called MK-4646 changes how the body processes rosuvastatin, a widely used cholesterol-lowering statin. Healthy volunteers will receive both drugs in a crossover design, and researchers will me…

This early-stage study looks at whether a single dose of ulonivirine changes how the body processes methadone. Fourteen healthy adults who are already on a stable methadone program will take methadone alone and then with ulonivirine. The goal is to measure drug levels in the bloo…

This early-stage study looks at how a common tuberculosis drug, rifampin, affects levels of a new HIV prevention medicine called MK-8527. Fourteen adults with latent TB (no active symptoms) will take MK-8527 with and without rifampin. The goal is to see if the two drugs can be us…

This early-stage trial is testing an investigational drug called MK-1406 in healthy adults. The goal is to compare what happens to the drug in the body when it's given as two injections versus three injections, and to check if it's safe and well-tolerated. Participants will recei…

This study investigates how a single dose of the drug ulonivirine is processed by the body in people with mild or moderate liver impairment compared to healthy volunteers. Researchers measure drug levels in the blood over time to see if liver function affects how the drug is brok…