Janssen-cilag Ltd.

This phase 3 study tests whether guselkumab can help close abnormal tunnels (fistulas) in the anal area caused by Crohn's disease. About 288 adults with active draining fistulas will receive either guselkumab or a placebo. The main goal is to see if the drug can achieve complete …

This study tests a drug called guselkumab in 120 adults with Crohn's disease. The goal is to see if it can heal all layers of the digestive tract, not just the surface. Doctors use MRI scans to measure healing at 48 weeks. This is an open-label study, meaning everyone knows they …

This study observes about 500 men with metastatic hormone-sensitive prostate cancer who are already starting treatment with either apalutamide or enzalutamide plus hormone therapy. Researchers will track PSA levels, quality of life, thinking skills, fatigue, and anxiety over time…