Federal Research Institute Of Pediatric Hematology, Oncology And Immunology

This study tests a new approach to prevent graft-versus-host disease (GVHD) in children and young adults with high-risk or relapsed blood cancers who need a stem cell transplant from a half-matched donor. The method involves giving special regulatory T cells along with the stem c…

This Phase 3 trial tests a powerful mix of chemotherapy, immunotherapy, and the child's own immune cells (natural killer cells) for children aged 1.5 to 18 with high-risk neuroblastoma that did not respond to initial treatment or has returned. The goal is to shrink tumors and imp…

This study tests a chemotherapy plan designed specifically for children (0-18 years) with acute myeloid leukemia (AML) and Down syndrome. The goal is to improve survival while reducing harsh side effects by using lower doses of chemotherapy drugs. About 100 children in Russia wil…

This study tests whether giving special immune cells (NK cells) before and after a stem cell transplant can help prevent leukemia from coming back in children and young adults (ages 0–25) with hard-to-treat acute leukemia. The NK cells are grown in a lab and come from the same do…