Douglas Mental Health University Institute

This phase 3 trial tests whether adding low-dose brexpiprazole to usual treatment can ease depressive episodes in people with bipolar I or II disorder. Researchers will measure changes in mood, thinking skills, and daily functioning over 8 weeks. The study enrolls adults aged 18 …

This study tests whether daridorexant, a sleep medication, can help the brain clear proteins linked to Alzheimer's disease. The trial includes 240 adults without dementia, regardless of sleep issues. Participants take the drug or a placebo nightly for one year, and researchers me…

This trial tests whether an accelerated form of brain stimulation, called intermittent theta burst stimulation (iTBS), is safe and feasible for young people at clinical high risk for psychosis. Participants receive either active or sham stimulation over five days, targeting a bra…

This study tests a quick, 5-day brain stimulation treatment for the 'negative symptoms' of schizophrenia, like low motivation and social withdrawal. 75 adults with stable schizophrenia will get either real or fake (placebo) stimulation. The goal is to see if this approach is safe…

This study looks at how stopping cannabis use for 28 days changes brain activity and memory in people with psychosis and in cannabis users without psychosis. Participants are randomly assigned to either quit cannabis or continue using, and undergo brain scans before and after the…