Blokhin's Russian Cancer Research Center

This study tests a combination of four drugs (irinotecan, dabrafenib, trametinib, and either cetuximab or panitumumab) as a second treatment option for people with advanced colorectal cancer that has spread and has a specific BRAF gene mutation. The goal is to see if this mix can…

This study tests a low dose of the immunotherapy drug nivolumab, alone or with chemotherapy, in people with advanced colorectal or stomach cancers that have a specific genetic feature (MSI/dMMR). The goal is to see if this approach can shrink tumors before surgery or control the …

This study tests a low-dose immunotherapy (nivolumab or pembrolizumab) in 30 people with a specific type of advanced colorectal cancer (MSI/dMMR). The goal is to see if 6 months of treatment can make the tumor disappear or shrink enough to avoid surgery. Participants have stage I…

This study is observing 1000 adults with recurrent malignant gliomas (aggressive brain tumors) to see how they respond to chemotherapy and targeted therapy. Researchers are tracking survival and tumor progression over time. The goal is to gather real-world data to guide future tr…

This study is looking back at medical records of 700 adults with colorectal cancer that has spread to the brain. Researchers want to see how different local treatments (like surgery or radiation) affect how long patients live and how long it takes for the cancer to grow again in …

This study reviews medical records from 230 adults across 15 hospitals in 2 countries to understand how brain metastases from stomach and esophageal cancers are treated. The goal is to see which local treatments (like surgery or radiation) work best and how long patients live aft…