Arrowhead Pharmaceuticals

This study tests an experimental drug called ARO-DIMERPA in adults with mixed hyperlipidemia (high cholesterol and high triglycerides). The goal is to see if it is safe and can lower harmful blood fats. About 78 participants will receive either the drug or a placebo. This is an e…

This program provides plozasiran to adults and adolescents with familial chylomicronemia syndrome (FCS) and adults with high-risk severe hypertriglyceridemia (SHTG) whose high triglyceride levels are not controlled by standard treatments. Participants receive injections every 3 m…

This study tests the long-term safety and effectiveness of a drug called plozasiran in adults with very high triglycerides, a condition that raises the risk of pancreatitis and heart disease. About 869 participants who completed earlier studies will receive injections every 3 mon…

This early-stage study tests a new drug called ARO-ATXN2 in 36 adults with spinocerebellar ataxia type 2, a rare genetic disorder that causes problems with balance and coordination. The main goal is to check the drug's safety and how the body processes it. Participants will recei…

This study tests an experimental drug called ARO-ALK7 in adults with obesity, some of whom also have type 2 diabetes. The goal is to check if the drug is safe and how it affects weight. Participants will receive either the drug or a placebo, and some will also take an existing we…

This study tests a drug called plozasiran in about 288 adults with severely high triglycerides who have had pancreatitis attacks. Participants get either the drug or a placebo every three months. The goal is to see if the drug can prevent future pancreatitis episodes and lower fa…

This study tests an experimental drug called ARO-DM1 in adults aged 18 to 65 with type 1 myotonic dystrophy, a genetic muscle disorder. The goal is to check the drug's safety and how the body processes it. Participants receive either the drug or a placebo, and the study involves …

This study tests a new medicine called ARO-INHBE in 180 adults with obesity, some of whom also have type 2 diabetes. The goal is to see if the drug is safe and helps with weight loss, either alone or with another weight-loss drug. Participants receive injections and are closely m…

This study tests a new drug called zodasiran in people aged 12 and older with homozygous familial hypercholesterolemia (HoFH), a rare genetic condition causing extremely high cholesterol. The goal is to see if the drug safely lowers LDL (bad) cholesterol over 12 months. Participa…

This study tests a new drug called ARO-DUX4 for people with facioscapulohumeral muscular dystrophy type 1 (FSHD1), a condition that causes muscle weakness. About 60 adults and teens will receive either the drug or a placebo to check its safety and how the body processes it. The g…

This study is testing an experimental drug called ARO-MAPT-SC in healthy volunteers and people with early Alzheimer's disease. The goal is to see if the drug is safe and how the body processes it. The drug works by targeting a protein linked to Alzheimer's, with the hope of slowi…

This study tests an inhaled medicine called ARO-RAGE in 36 adults with mild asthma. The goal is to see if it can improve small airway function after breathing in an allergen. Participants will receive either the drug or a placebo and have their lung function measured over time.