UROTHELIAL CARCINOMA (UC)

This study tests a two-part approach for people with advanced solid tumors that cannot be removed by surgery. First, a radioactive tracer helps doctors see the tumor on scans. Then, a therapeutic dose of radiation is given to destroy cancer cells. The goal is to find the safest a…

This study tests whether adding a precise, high-dose type of radiation (stereotactic body radiation therapy, or SBRT) to standard treatments like chemotherapy or immunotherapy can better control bladder cancer that has spread to a limited number of places (up to 3 spots). The tri…

This early-stage study tests a new drug called IDE892, alone or with other medicines, in people with advanced solid tumors that lack a gene called MTAP. The goal is to see if the drug is safe and can shrink tumors. About 260 adults with certain cancers (like lung, stomach, bladde…

This early-stage trial tests a new drug called XL092, alone or with other immune-boosting drugs, in people with advanced solid tumors that have stopped responding to standard treatments. The goal is to find safe doses and see if the combination can shrink tumors or slow their gro…

This study tests whether a simple blood and urine test (liquid biopsy) can help diagnose, monitor treatment response, and predict recurrence in people with urothelial carcinoma (a type of bladder cancer). Researchers will compare these non-invasive tests to standard tissue biopsi…

This study compares two types of scans—CT and MRI—to see which one is better at determining if bladder cancer has spread into the muscle layer. About 150 adults with newly diagnosed bladder cancer will receive both scans before surgery, and the results will be checked against tis…

This study is testing a new type of PET/CT scan that uses a special tracer called 18F-T2 to find cancers that have high levels of a protein called CAIX. About 200 adults with cancers like kidney, bladder, lung, or breast cancer will get this scan to see if it works better than th…

This study follows 300 Korean adults with high-grade upper tract urothelial carcinoma to monitor for cancer recurrence after chemotherapy and surgery. Researchers collect blood samples and medical data over time to build a platform that may help predict when the cancer comes back…