Transthyretin amyloidosis with cardiomyopathy
Clinical trials for Transthyretin amyloidosis with cardiomyopathy explained in plain language.
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New drug aims to cut deaths and heart crises in rare amyloidosis
Disease control Recruiting nowThis Phase 3 study tests a drug called nucresiran in 1250 people with ATTR amyloidosis, a rare disease where abnormal proteins damage the heart. Participants receive either nucresiran or a placebo every 6 months. The goal is to see if the drug reduces deaths and heart-related hos…
Matched conditions: TRANSTHYRETIN AMYLOIDOSIS WITH CARDIOMYOPATHY
Phase 3 • Sponsor: Alnylam Pharmaceuticals • Aim: Disease control
Last updated Sep 18, 2026 00:00 UTC
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Gene-Editing breakthrough: could a single dose stop a deadly heart condition?
Disease control Recruiting nowThis study tests a single dose of NTLA-2001, a gene-editing therapy, in 1200 adults with transthyretin amyloidosis with cardiomyopathy (ATTR-CM), a condition where abnormal protein builds up in the heart. The goal is to see if it reduces heart-related deaths and events compared t…
Matched conditions: TRANSTHYRETIN AMYLOIDOSIS WITH CARDIOMYOPATHY
Phase 3 • Sponsor: Intellia Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 12:01 UTC
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New study tracks safety of eplontersen in patients with liver transplants
Knowledge-focused Recruiting nowThis observational study monitors the long-term safety of eplontersen, a treatment for transthyretin amyloidosis, in patients who have had a liver transplant or have severe liver impairment. Researchers will track side effects, lab changes, and serious health events in about 320 …
Matched conditions: TRANSTHYRETIN AMYLOIDOSIS WITH CARDIOMYOPATHY
Sponsor: AstraZeneca • Aim: Knowledge-focused
Last updated Sep 16, 2026 00:00 UTC
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Global study tracks Real-World impact of new heart drug
Knowledge-focused Recruiting nowThis study will follow about 2000 adults with a heart condition called ATTR-CM, where abnormal proteins build up and weaken the heart. Researchers want to see how patients do on a drug called vutrisiran in everyday medical care, not just in a controlled trial. They will measure s…
Matched conditions: TRANSTHYRETIN AMYLOIDOSIS WITH CARDIOMYOPATHY
Sponsor: Alnylam Pharmaceuticals • Aim: Knowledge-focused
Last updated Sep 11, 2026 00:00 UTC