Transfusion-dependent thalassemia
Clinical trials for Transfusion-dependent thalassemia explained in plain language.
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Can a One-Time gene infusion free patients from transfusions?
Cure Not yet recruitingThis trial tests a gene therapy called YOLT-204 in people aged 14 to 35 with sickle cell disease or transfusion-dependent thalassemia. The goal is to see if a single intravenous dose can safely boost fetal hemoglobin levels, potentially reducing or eliminating the need for blood …
Matched conditions: TRANSFUSION-DEPENDENT THALASSEMIA
Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology • Aim: Cure
Last updated Aug 21, 2026 00:00 UTC
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New drug YOLT-204 aims to reduce transfusions in blood disorders
Disease control Not yet recruitingThis early-phase trial will test a single dose of a new drug called YOLT-204 in 18 children and teens with transfusion-dependent β-thalassemia or sickle cell disease. The goal is to see if it is safe and can raise fetal hemoglobin levels enough to reduce the need for blood transf…
Matched conditions: TRANSFUSION-DEPENDENT THALASSEMIA
Early phase 1 • Sponsor: Guangzhou Women and Children's Medical Center • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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Talking therapy could help thalassemia patients take their meds
Symptom relief Not yet recruitingThis study tests whether motivational interviewing, a type of counseling, can help adults with beta-thalassemia major follow their iron chelation therapy more consistently. Forty-five participants in Oman will receive three one-on-one sessions with a nurse over six to eight weeks…
Matched conditions: TRANSFUSION-DEPENDENT THALASSEMIA
Sponsor: Oman Ministry of Health • Aim: Symptom relief
Last updated Jun 27, 2026 14:01 UTC