Stroke, acute ischemic

This trial investigates whether giving a low dose of the clot-busting drug alteplase directly into the brain artery, right after successful mechanical clot removal, can improve recovery in people with a severe stroke caused by a large vessel blockage. About 416 adults who have ha…

This study tests whether lying in a slight head-down position (20 degrees) can help people recover from a moderate stroke caused by narrowed arteries. Researchers will compare this position plus standard care to standard care alone in 600 participants. The goal is to see if more …

This study tests whether giving a clot-busting drug (rhTNK-tPA) before a clot-removal procedure helps stroke patients who arrive 4.5 to 24 hours after symptoms start. About 820 adults with a blocked large artery in the brain will receive either the drug or a placebo. The goal is …

This study compares two treatments for people with a severe stroke caused by a large blood clot. One group gets standard care (medication), and the other gets standard care plus a procedure to remove the clot. The goal is to see if clot removal leads to better recovery and less d…

This study compares two treatments for stroke patients whose brain arteries remain blocked after initial clot removal, due to underlying hardening of the arteries (atherosclerosis). About 498 participants will be randomly assigned to receive either urgent stenting or continued st…

Researchers are testing whether MLC901 (NeuroAiD II), a natural capsule, helps people recover after a mild to moderate ischemic stroke. The trial enrolls 80 adults aged 18 to 80 who are within 2 to 10 days of their stroke. Participants receive either MLC901 plus standard stroke c…