SMOLDERING MULTIPLE MYELOMA
Clinical trials for SMOLDERING MULTIPLE MYELOMA explained in plain language.
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New hope for High-Risk smoldering myeloma: drug may delay active disease
Disease control OngoingThis study tests whether the drug daratumumab can delay or prevent smoldering multiple myeloma from turning into active multiple myeloma. About 390 people with high-risk smoldering myeloma will either receive daratumumab injections or be closely monitored without treatment. The g…
Matched conditions: SMOLDERING MULTIPLE MYELOMA
Phase: PHASE3 • Sponsor: Janssen Research & Development, LLC • Aim: Disease control
Last updated May 26, 2026 10:27 UTC
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New drug aims to halt early blood cancer before it starts
Disease control OngoingThis study tests a drug called daratumumab in people with early blood conditions (MGUS or smoldering myeloma) that may turn into active cancer. The goal is to see if the drug can deeply reduce or eliminate abnormal cells, potentially delaying or preventing progression. About 42 a…
Matched conditions: SMOLDERING MULTIPLE MYELOMA
Phase: PHASE2 • Sponsor: Dana-Farber Cancer Institute • Aim: Disease control
Last updated May 26, 2026 10:22 UTC
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New vaccine combo aims to halt smoldering myeloma before it strikes
Disease control OngoingThis early-phase study tests a cancer vaccine (PVX-410) with two other drugs (citarinostat and lenalidomide) in people with smoldering multiple myeloma, a pre-cancer condition. The goal is to see if the combination is safe and can boost the immune system to control the disease. N…
Matched conditions: SMOLDERING MULTIPLE MYELOMA
Phase: PHASE1 • Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated May 22, 2026 13:54 UTC
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CAR-T therapy targets smoldering myeloma before it becomes active cancer
Disease control OngoingThis study tests a CAR-T cell therapy called cilta-cel in 20 people with high-risk smoldering myeloma, a pre-cancer condition. The treatment uses a patient's own immune cells, modified to attack myeloma cells, along with chemotherapy. The goal is to see if it is safe and can dela…
Matched conditions: SMOLDERING MULTIPLE MYELOMA
Phase: PHASE2 • Sponsor: Dana-Farber Cancer Institute • Aim: Disease control
Last updated May 20, 2026 11:56 UTC
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Can a pill keep myeloma at bay after transplant? major trial seeks answers
Disease control OngoingThis study tested whether taking lenalidomide (a drug that helps the immune system fight cancer) after a stem cell transplant could delay the return of multiple myeloma. About 460 patients with active myeloma received either lenalidomide or a placebo after their transplant. The g…
Matched conditions: SMOLDERING MULTIPLE MYELOMA
Phase: PHASE3 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 19, 2026 11:46 UTC
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Can a drug delay cancer in high-risk patients before symptoms start?
Disease control OngoingThis study compares the drug lenalidomide to simply watching and waiting in 226 people with high-risk smoldering multiple myeloma, a condition that often turns into active cancer. The goal is to see if lenalidomide can delay progression and improve survival without causing seriou…
Matched conditions: SMOLDERING MULTIPLE MYELOMA
Phase: PHASE3 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 15, 2026 11:56 UTC
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Diabetes drug metformin tested to stop blood cancer before it starts
Prevention OngoingThis study tests whether metformin, a widely used diabetes medicine, can stop early blood conditions (MGUS and smoldering myeloma) from turning into multiple myeloma. About 60 people with higher-risk MGUS or low-risk smoldering myeloma will receive either metformin or a placebo p…
Matched conditions: SMOLDERING MULTIPLE MYELOMA
Phase: PHASE2 • Sponsor: Dana-Farber Cancer Institute • Aim: Prevention
Last updated May 26, 2026 10:27 UTC
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Plant-Based diet trial aims to stop precancerous blood condition from turning into multiple myeloma
Prevention OngoingThis study tests whether a plant-based diet is practical for overweight people with MGUS or smoldering multiple myeloma, two early blood conditions that can lead to multiple myeloma. Over 12 weeks, 23 participants will follow a whole-food, plant-based diet to see if they can stic…
Matched conditions: SMOLDERING MULTIPLE MYELOMA
Phase: NA • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Prevention
Last updated May 26, 2026 10:26 UTC
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Scientists create tissue bank to unlock secrets of rare blood cancers
Knowledge-focused OngoingThis study collects bone marrow and blood samples, along with medical history, from people with multiple myeloma, Waldenstrom macroglobulinemia, and related conditions. The samples are stored in a tissue bank for researchers to study the causes and biology of these diseases. The …
Matched conditions: SMOLDERING MULTIPLE MYELOMA
Sponsor: Dana-Farber Cancer Institute • Aim: Knowledge-focused
Last updated May 26, 2026 10:23 UTC