SMOLDERING MULTIPLE MYELOMA

This early-stage study is testing whether a combination of a cancer vaccine and other drugs can help control smoldering multiple myeloma, an early precursor to a blood cancer. The trial involves 19 participants with this condition who are at higher risk of their disease progressi…

This study is testing whether a CAR-T cell therapy called cilta-cel can safely treat people with high-risk smoldering myeloma, an early stage of blood cancer that hasn't yet caused symptoms. Researchers are giving 20 participants this immune therapy, which involves modifying thei…

This study is testing whether starting a drug called lenalidomide early can delay or prevent the progression of a pre-cancerous blood condition (high-risk smoldering myeloma) to active cancer. It compares the drug to a 'watch and wait' approach in over 200 patients. The main goal…

This study tested whether taking a daily pill called lenalidomide after a stem cell transplant could help patients with multiple myeloma live longer without their cancer getting worse. About 460 patients who had their own stem cells transplanted were randomly assigned to receive …

This study is testing whether the drug daratumumab can prevent or delay the progression to active multiple myeloma in people with high-risk early-stage conditions. It involves 42 adults with either high-risk MGUS or low-risk smoldering multiple myeloma. The goal is to see if this…

This study is testing whether regular injections of a drug called daratumumab can delay or prevent high-risk smoldering multiple myeloma from progressing to active multiple myeloma, which requires treatment. It involves 390 participants who have the high-risk form of this precanc…

This small pilot study is testing whether a 12-week whole food, plant-based diet is practical and helpful for overweight people with early blood cell conditions (MGUS or smoldering myeloma) that can sometimes turn into cancer. Researchers want to see if participants can stick to …

This study is testing whether metformin, a common diabetes medication, can prevent people with early blood cell conditions (MGUS and smoldering myeloma) from developing full multiple myeloma, a type of blood cancer. About 60 participants will take either metformin or a placebo pi…

This study collects blood and bone marrow samples from people with multiple myeloma and related blood cancers to build a research database. Participants also provide medical history through a questionnaire. The goal is to help scientists understand these diseases better and devel…