SMALL BOWEL ADENOCARCINOMA

This study tests a four-drug chemotherapy combination (NALIRIFOX) in people with advanced small bowel cancer that cannot be removed by surgery. The treatment is given through a vein in 28-day cycles. Up to 36 adults will take part. The main goal is to see how many patients' tumor…

This early-stage trial tests a two-step vaccine strategy in adults with advanced colorectal or small bowel cancer that has not responded to standard treatments. Participants first receive one vaccine injection, followed by two doses of a second vaccine four weeks apart. The goal …

This study tests whether the immunotherapy drug dostarlimab works better than standard chemotherapy as the first treatment for people with advanced cancers that have specific genetic markers (dMMR/MSI). The cancers studied are rare types like pancreatic, stomach, and small bowel …

This study reviews past medical records of 400 people with Lynch syndrome who had a small bowel capsule endoscopy (a camera in a pill) to screen for early growths or cancer. The goal is to see how well this test finds precancerous or cancerous lesions in the small bowel. Results …

This study looks at how well a tiny camera you swallow (videocapsule endoscopy) can find early signs of small bowel cancer in people with Lynch syndrome. About 100 adults with Lynch syndrome will swallow the camera pill as part of their regular care. Researchers will track how ma…