Refractory melanoma
Clinical trials for Refractory melanoma explained in plain language.
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New combo tackles tough melanoma
Disease control Stopped earlyThis phase II trial is testing whether a combination of two drugs, rigosertib and pembrolizumab, can help people with advanced melanoma that no longer responds to standard immunotherapy. The study involves 7 participants with unresectable or metastatic melanoma. The goal is to se…
Matched conditions: REFRACTORY MELANOMA
Phase 2 • Sponsor: Vanderbilt-Ingram Cancer Center • Aim: Disease control
Last updated Sep 18, 2026 00:00 UTC
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Experimental melanoma combo trial shutters after just one patient
Disease control Stopped earlyThis phase II trial tested a mix of a personalized dendritic cell vaccine and three immune-boosting drugs in people with advanced melanoma that no longer responded to PD-1/PD-L1 checkpoint inhibitors. The goal was to see if the combination could shrink tumors or slow their growth…
Matched conditions: REFRACTORY MELANOMA
Phase 2 • Sponsor: Roswell Park Cancer Institute • Aim: Disease control
Last updated Jun 27, 2026 09:07 UTC