Refractory childhood malignant solid neoplasm
Clinical trials for Refractory childhood malignant solid neoplasm explained in plain language.
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Targeted drug conjugate CBX-12 tested against childhood sarcomas
Disease control Not yet recruitingResearchers are testing a drug called CBX-12 in children and young adults with solid tumors that have returned or stopped responding to treatment, including rhabdomyosarcoma and Ewing sarcoma. CBX-12 pairs a tumor-seeking peptide with exatecan, a chemotherapy drug that blocks can…
Matched conditions: REFRACTORY CHILDHOOD MALIGNANT SOLID NEOPLASM
Phase 1/2 • Sponsor: Children's Oncology Group • Aim: Disease control
Last updated Sep 21, 2026 17:00 UTC
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A pill that blocks RAS: can it help children whose tumors came back?
Disease control Not yet recruitingResearchers are testing daraxonrasib, an experimental pill that blocks RAS proteins, in children with solid tumors that have come back or stopped responding to treatment. The tumors include neuroblastoma and rhabdomyosarcoma, and all carry RAS mutations. The trial has two parts: …
Matched conditions: REFRACTORY CHILDHOOD MALIGNANT SOLID NEOPLASM
Phase 1/2 • Sponsor: Children's Oncology Group • Aim: Disease control
Last updated Sep 17, 2026 00:00 UTC