RECURRENT WHO GRADE 2 GLIOMA

This study is testing an oral medication called tipifarnib in children and young adults (ages 1-21) whose advanced solid tumors, lymphoma, or histiocytic disorders have a specific genetic change in a gene called HRAS. The goal is to see if the drug can shrink tumors and control t…

This study is testing how well a drug called selpercatinib works for children and young adults with advanced or hard-to-treat cancers that have a specific genetic change in the RET gene. The drug is designed to block the growth of cancer cells with this change. Participants take …

This study is for children and young adults whose low-grade brain tumor has come back or stopped responding to treatment. It aims to find out if combining two drugs, selumetinib and vinblastine, works better than using selumetinib alone to control the tumor and prevent it from gr…

This early-stage study is testing a new drug combination for adults whose aggressive brain cancer (glioblastoma) has returned. Researchers want to find the safest and most effective dose of an experimental drug called triapine when given with the standard chemotherapy temozolomid…

This study is testing a drug called ivosidenib in children and young adults (ages 1-21) whose cancers have returned or not responded to standard treatments. The drug is given as a daily pill and is designed to specifically block cancer growth in tumors that have a particular gene…