OSTEO ARTHRITIS OF THE KNEE

This study compares two ways of aligning the knee during a bone-cutting surgery (high tibial osteotomy) for people with knee arthritis and bow-legged deformity. One method uses the patient's natural joint line (kinematic), the other uses a straight mechanical axis. The trial will…

This study compares two ways to align the knee during total knee replacement in 80 obese adults (BMI 35+). One method uses robotic or computer assistance, the other uses traditional manual tools. The goal is to see which leads to better knee motion and recovery after surgery.

This study tests a wearable device that delivers long-duration ultrasound to the knee to reduce pain and improve function in people with mild to moderate knee osteoarthritis. About 240 adults aged 65-85 with knee pain will use the device at home for 12 weeks. The goal is to see i…

This early study tests the safety of a single injection of a new polymer called ABR1 for knee osteoarthritis. About 25 adults with moderate to severe knee pain will receive the injection and be followed for 12 weeks. The main goal is to see if the treatment causes any side effect…

This study compares two types of total knee replacement surgery for people with knee osteoarthritis: one done manually and one assisted by a robotic device (VELYS). About 346 participants will be randomly assigned to one of the two surgeries and followed for a year to see which l…

This study tests a gel called Sensovisc, injected into the knee joint to reduce pain and improve movement in people with knee osteoarthritis. About 75 adults with moderate knee arthritis will receive the gel and be followed for 6 months. The goal is to see if the gel safely eases…

This study looks at whether a program called PREP helps veterans who need total knee replacement for osteoarthritis. The program includes exercises before surgery and a week of intense rehab after. Researchers will check pain, function, and mental health for up to a year after su…