NF1
Clinical trials for NF1 explained in plain language.
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New drug cocktail takes on rare nerve tumors
Disease control Recruiting nowThis early-phase trial tests a combination of three drugs—selumetinib, ZEN-3694, and durvalumab—in people with advanced sarcomas, including malignant peripheral nerve sheath tumors (MPNST) linked to NF1. The study first checks safety and dosing, then looks at whether the treatmen…
Matched conditions: NF1
Phase 2 • Sponsor: University of Alabama at Birmingham • Aim: Disease control
Last updated Aug 26, 2026 00:00 UTC
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Could a cold sore virus shrink NF1 skin tumors?
Disease control Recruiting nowThis early study tests whether a drug called IMLYGIC, made from a modified herpes virus, can be safely injected into painful or disfiguring skin tumors in adults with NF1. Ten participants will receive up to 8 injections over 4 months. The goal is to see if the treatment is toler…
Matched conditions: NF1
Phase 1 • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Jun 27, 2026 12:31 UTC
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New drug shows promise for NF1 skin tumors in early trial
Disease control Recruiting nowThis study tests a drug called mirdametinib in adults with neurofibromatosis type 1 (NF1) who have skin tumors called cutaneous neurofibromas. The goal is to find a safe dose and see if the drug can shrink these tumors. About 24 people will take the drug daily or on a three-week-…
Matched conditions: NF1
Phase 1/2 • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC