MYELOID MALIGNANCY

This study is testing the safety and dosing of a new oral drug called lisaftoclax, both by itself and combined with other cancer drugs, for people with acute myeloid leukemia (AML) that has returned or not responded to prior treatment. The goal is to find the safest and most effe…

This study is testing whether giving the drug azacitidine after a stem cell transplant can help maintain the donor's healthy cells in patients with blood cancers like AML and MDS. The goal is to reduce the risk of the cancer returning by preventing the patient's own cells from ta…

This study is testing whether a new three-drug combination can help control acute myeloid leukemia (AML) that has returned or hasn't responded to previous treatments. The trial will enroll 72 adults with relapsed or refractory AML to receive the drug combination and closely monit…

This early-stage trial is testing if adding two anti-cancer drugs, decitabine and venetoclax, to a standard stem cell transplant procedure is safe for adults with high-risk blood cancers like acute myeloid leukemia (AML). The main goal is to find the safest dose and see if this c…

This study is testing whether a telehealth program helps older patients with serious blood cancers have better conversations with their doctors about future care wishes. It aims to see if these structured video calls reduce patient anxiety and distress, and help more people compl…

This study is testing a digital tool designed to help patients with serious blood cancers make difficult decisions about bone marrow transplants. The tool uses real video stories from past patients and exercises to help clarify personal values. Researchers want to see if this app…

This study aims to find people at risk for developing blood cancers and bone marrow failure syndromes before they get sick. Researchers will use advanced genetic testing on blood, bone marrow, and saliva samples from up to 2,000 participants. The goal is to identify early warning…