METASTATIC GASTRIC ADENOCARCINOMA

This study is for people with advanced stomach cancer that has spread and who have already tried one prior treatment. It tests a combination of three drugs (ramucirumab, nal-IRI, and trifluridine/tipiracil) to see if they can shrink tumors and help people live longer. The trial h…

This study compares two chemotherapy combinations for people with advanced stomach, esophageal, or gastroesophageal junction cancer that cannot be removed by surgery or has spread. About 382 participants will receive either the standard FOLFOX chemo (with or without the immunothe…

This study is for people with advanced stomach or esophageal cancer that has spread. It tests whether adding the immunotherapy drug nivolumab to the usual two-drug treatment (paclitaxel and ramucirumab) helps control the cancer longer. About 224 participants will be randomly assi…

This early-phase trial tests two drugs, pembrolizumab and lenvatinib, in about 15 people with advanced stomach or gastroesophageal cancer that has spread or can't be surgically removed. Pembrolizumab helps the immune system fight cancer, while lenvatinib blocks enzymes that help …

This study tests whether adding the drug ivonescimab to standard chemotherapy helps shrink tumors in people with advanced stomach or esophageal cancer. About 88 participants will receive treatment every two weeks. The main goal is to see if more patients respond to the combinatio…

This study tests a personalized vaccine made from a patient's own tumor proteins, combined with the immunotherapy drug pembrolizumab, for people with advanced solid tumors (like breast, lung, or skin cancer). The goal is to see if the combination is safe and helps the immune syst…

This study tests an experimental oral drug called zongertinib, which blocks HER2 (a protein that fuels cancer growth). It is given alone or with other standard treatments to adults with advanced HER2+ breast, stomach, or colorectal cancer that has spread and no longer responds to…

This early-phase trial tests a new method of delivering chemotherapy directly into the abdomen as a fine mist under pressure (PIPAC) for stomach cancer that has spread to the lining of the belly. About 30 adults who have already tried one standard treatment will receive this mist…

This study tests if a shot under the skin works as well as an IV drip for a cancer drug (tislelizumab) combined with chemotherapy in adults with advanced stomach or gastroesophageal junction cancer that cannot be removed by surgery or has spread. About 351 participants will recei…

This study tests a mix of immune cells (agenT-797) and three immunotherapy drugs (botensilimab, balstilimab, ramucirumab) plus chemotherapy (paclitaxel) for people with advanced stomach, esophageal, or gastro-esophageal junction cancer that has worsened after one prior treatment.…