MELASMA

This study tests whether a cream made from the diabetes drug metformin can treat facial melasma as well as the standard Kligman's regimen, but with fewer side effects like redness or burning. About 82 women aged 35-55 with melasma will use either the metformin cream or Kligman's …

This study tests whether taking tranexamic acid pills along with a skin needling treatment that delivers glutathione works better for melasma than either treatment alone. About 42 women with facial melasma will be enrolled. The goal is to reduce the dark patches and improve how p…

This study tests whether a metformin cream or a tranexamic acid cream works better for reducing melasma, a common skin condition causing dark patches on the face. Seventy adults with melasma will apply one of the creams daily for 12 weeks. Researchers will measure changes in skin…

This study will test whether adding MELA B3 serum to a 35% glycolic acid peel works better than the peel alone for treating dark spots (melasma, post-inflammatory hyperpigmentation, and sun spots) and signs of aging. About 80 adults aged 30 to 70 with mild to moderate hyperpigmen…

This study compares two topical creams—tranexamic acid and ethyl ascorbic acid—to see which works better for treating melasma, a skin condition that causes dark patches on the face. Researchers will enroll 128 adults aged 18 to 50 with melasma and measure improvement using a stan…