MALIGNANT SOLID TUMORS

This study tests an experimental drug called SHR-1681 in about 300 adults with advanced solid tumors that have not responded to standard treatments. The main goals are to find the safest dose and check for side effects. Researchers will also measure how the drug moves through the…

This study tests a new drug called SHR-4849 combined with other cancer medicines in people with advanced solid tumors. The goal is to see if the combination is safe and can shrink tumors. About 120 adults aged 18 to 75 with measurable tumors and adequate organ function are eligib…

This study tests a drug called asciminib for people with chronic myeloid leukemia (CML) whose first treatment did not work well or caused side effects. The goal is to see if asciminib can lower the amount of leukemia cells in the blood to very low levels within 12 months. About 4…

This study tests a new drug called SHR-7787 combined with other anti-cancer medicines in people with advanced solid tumors that cannot be removed by surgery. The goal is to find safe doses and see if the combination shrinks tumors or slows their growth. About 400 adults with vari…

This study tests a new drug called TAK-505 for the first time in people with advanced solid tumors that cannot be removed by surgery. The main goals are to check the drug's safety, find the best dose, and see if it can shrink or slow tumor growth. About 151 adults with certain ca…

This study collects biological samples and health information from up to 10,000 people with rare solid tumors or a family history of them. The goal is to learn how these tumors develop and change over time. Participants provide saliva, blood, or tumor tissue and answer yearly hea…

This study is testing whether a new type of MRI scan, which uses a special imaging agent called hyperpolarized pyruvate, gives the same results each time it is used in the same person. About 109 people with solid tumors will have two of these scans to check for consistency. The g…