Major non-cardiac surgery
Clinical trials for Major non-cardiac surgery explained in plain language.
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Can a common steroid shield surgery patients from sepsis and lung failure?
Prevention CompletedMajor non-cardiac surgery triggers a strong inflammatory response that can lead to sepsis, lung failure, and death. Researchers are testing whether two intravenous doses of dexamethasone, a steroid, given at the end of surgery and 24 hours later can dampen that response and reduc…
Matched conditions: MAJOR NON-CARDIAC SURGERY
Phase 3 • Sponsor: Nantes University Hospital • Aim: Prevention
Last updated Sep 16, 2026 00:00 UTC
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Sleep hormone may ward off Post-Surgery delirium in seniors
Prevention CompletedThis study tested whether giving melatonin, a natural sleep hormone, could prevent delirium (sudden confusion) in elderly patients after major non-cardiac surgery. Researchers enrolled 88 patients aged 65 and older across multiple hospitals. The goal was to see if a larger trial …
Matched conditions: MAJOR NON-CARDIAC SURGERY
Sponsor: McMaster University • Aim: Prevention
Last updated Jun 26, 2026 15:50 UTC