LYMPHOMA, NON-HODGKIN

This study tests a new treatment for children and young adults (ages 3-39) with B-cell cancers like leukemia or lymphoma that have come back after standard therapy. The treatment uses a patient's own immune cells, which are modified in a lab to target two cancer proteins (CD19 an…

This early-phase study tests an experimental drug called JNJ-95566692, a trispecific antibody designed to attach to three targets on lymphoma cells and immune cells to help the body fight the cancer. About 130 adults with B-cell non-Hodgkin lymphoma that has returned or not respo…

This study tests whether giving a targeted therapy drug that matches a specific gene change in a person's cancer can shrink tumors or stop them from growing. It includes adults with advanced solid tumors, multiple myeloma, or certain lymphomas who have no standard treatment optio…

This early-phase study tests a new drug, ONM-501, injected directly into tumors, either alone or with another drug (cemiplimab), in people with advanced solid tumors or lymphomas that have not responded to other treatments. The main goals are to find the safest dose and understan…

This study tests a new immunotherapy drug, MK-1045, in about 200 people with two types of non-Hodgkin lymphoma (follicular lymphoma and diffuse large B-cell lymphoma) that have not responded to at least two prior treatments. The main goals are to check safety and see if the cance…

This study tests whether the drug epcoritamab can help people with follicular lymphoma whose cancer did not completely go away after their first chemotherapy and immunotherapy treatment. About 35 adults with advanced-stage lymphoma will receive epcoritamab as a second treatment. …

This study tests a new treatment called JNJ-90014496 (prizlo-cel) for adults with B-cell non-Hodgkin lymphoma that has come back or not responded to other treatments. The therapy uses a patient's own immune cells, modified to target two markers on cancer cells (CD19 and CD20). Th…

This early-phase trial tests a new drug called TLN-121, alone or with other lymphoma treatments, in about 180 adults whose Non-Hodgkin Lymphoma has returned or not responded to prior therapy. The main goals are to check safety, find the right dose, and see if the drug shrinks tum…

This study tests whether a connected scale can help monitor people with lymphoma or multiple myeloma who are receiving chemotherapy. Thirty participants will weigh themselves daily at home for about 7 weeks. The medical team will receive alerts if weight or heart rate changes abn…

This study is testing whether a 12-week program that encourages lymphoma patients to take frequent breaks from sitting can improve their heart health and reduce side effects from chemotherapy. The program includes supervised activity breaks during infusion appointments and home-b…

This study collects tumor tissue from people with Hodgkin or non-Hodgkin lymphoma to learn more about the biology of lymphoma cells. Participants must already be scheduled for a routine tissue removal procedure (like a tonsillectomy). No treatment is given; the goal is simply to …

This study collects blood, bone marrow, and tumor samples from 500 adults with cancer or pre-cancerous conditions. Researchers will use these samples to learn why some cancers respond differently to treatment. The goal is to develop more effective therapies in the future.

This study is for people with advanced cancer (solid tumors, lymphoma, or multiple myeloma) that has stopped responding to standard treatments. Researchers will test the tumor's genes to find a targeted drug that might work. The goal is to learn from real-world use which drugs he…

This study is testing an artificial intelligence system to detect when lymphoma patients are not taking their oral medications as prescribed. The goal is to help doctors intervene earlier and improve treatment success. About 210 adult patients with non-Hodgkin lymphoma will parti…

This study looks at why some families have more blood cancers like lymphoma, leukemia, and myeloma. Researchers will study the genes and environment of 3000 people who have at least two living relatives with these cancers. The goal is to find inherited factors that raise risk, no…

This study collects blood, urine, bone marrow, and tissue samples from adults with lymphoid cancers or precancerous conditions. The goal is to help researchers better understand these diseases, which may lead to new ways to diagnose or treat them. No treatment is given as part of…