IMMUNODEFICIENCY
Clinical trials for IMMUNODEFICIENCY explained in plain language.
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New trial aims to boost COVID-19 protection for vulnerable patients
Disease control Recruiting nowThis study is testing whether giving a longer course of the antiviral Paxlovid (10 days instead of 5) or combining it with another antiviral (remdesivir) helps immunocompromised people clear COVID-19 faster. About 256 participants with mild to moderate COVID-19 and weakened immun…
Matched conditions: IMMUNODEFICIENCY
Phase: PHASE2 • Sponsor: Calmy Alexandra • Aim: Disease control
Last updated Jun 23, 2026 11:57 UTC
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Could a stem cell transplant stop VEXAS? new trial aims to find out
Disease control Recruiting nowThis study tests whether a stem cell transplant from a healthy donor can treat VEXAS syndrome, a rare and serious autoinflammatory disease. About 54 adults aged 18 to 75 with severe VEXAS that hasn't responded to standard treatments will receive donor stem cells after chemotherap…
Matched conditions: IMMUNODEFICIENCY
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 18, 2026 11:53 UTC
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New immune cell boost may shield kids from Post-Transplant infections
Disease control Recruiting nowThis study tests whether adding memory immune cells (CD45RO) to a stem cell transplant can help children fight off dangerous viral and fungal infections after the procedure. The transplant uses donor stem cells that have been stripped of certain cells to prevent graft-versus-host…
Matched conditions: IMMUNODEFICIENCY
Phase: PHASE1, PHASE2 • Sponsor: Children's Hospital of Philadelphia • Aim: Disease control
Last updated Jun 18, 2026 11:50 UTC
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New hope for vulnerable patients: shorter, stronger COVID-19 treatment on trial
Disease control Recruiting nowThis study is for people with weakened immune systems who have mild or no symptoms of COVID-19. It tests whether using two antiviral drugs together or taking the standard drug for a longer time can clear the virus faster. About 256 participants will be randomly assigned to differ…
Matched conditions: IMMUNODEFICIENCY
Phase: PHASE2 • Sponsor: ANRS, Emerging Infectious Diseases • Aim: Disease control
Last updated Jun 17, 2026 12:10 UTC
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New stem cell trial offers hope for rare immune disorder
Disease control Recruiting nowThis study tests whether a stem cell transplant from a healthy donor can treat GATA2 deficiency, a rare genetic condition that weakens the immune system and raises the risk of leukemia. Participants aged 6 to 70 receive chemotherapy or radiation before the transplant to prepare t…
Matched conditions: IMMUNODEFICIENCY
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 08, 2026 13:04 UTC
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Massive gene hunt aims to unlock secrets of immune disorders
Knowledge-focused Recruiting nowThis study is looking for the genes that cause certain immune system problems. Researchers want to understand why some people get sick and others don't, even in the same family. Up to 5,000 people with immune disorders and their relatives will give blood or cheek cell samples for…
Matched conditions: IMMUNODEFICIENCY
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Jun 23, 2026 11:58 UTC
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New study to reveal hidden weaknesses in vaccines for Immune-Compromised patients
Knowledge-focused Recruiting nowThis study looks at how well vaccines against respiratory viruses (like flu or COVID-19) work in people with weakened immune systems, including those with blood cancers. Researchers will measure both antibody and T cell responses after vaccination. The goal is to understand why v…
Matched conditions: IMMUNODEFICIENCY
Sponsor: University of Cologne • Aim: Knowledge-focused
Last updated Jun 22, 2026 12:07 UTC
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Parkinson's drug may weaken immunity: new study investigates
Knowledge-focused Recruiting nowThis study looks at whether clozapine, a drug used to treat psychosis in Parkinson's disease, weakens the immune system over time. Researchers will measure immune markers in 24 patients before and after 6 and 12 months of treatment. The goal is to understand infection risks in th…
Matched conditions: IMMUNODEFICIENCY
Phase: PHASE4 • Sponsor: Centre Hospitalier Universitaire, Amiens • Aim: Knowledge-focused
Last updated Jun 15, 2026 19:07 UTC