Homologous recombination deficiency
Clinical trials for Homologous recombination deficiency explained in plain language.
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Can a Chemo-Targeted drug combo outsmart Treatment-Resistant prostate cancer?
Disease control Stopped earlyThis phase 2 trial is testing whether giving two chemotherapy drugs (docetaxel and carboplatin) followed by a maintenance drug called rucaparib can help men with metastatic castration-resistant prostate cancer that has specific DNA repair defects. The idea is that the chemo shrin…
Matched conditions: HOMOLOGOUS RECOMBINATION DEFICIENCY
Phase 2 • Sponsor: University of Washington • Aim: Disease control
Last updated Aug 28, 2026 00:00 UTC
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New test may expand olaparib benefits to more ovarian cancer patients
Knowledge-focused Stopped earlyThis study tested a new lab method (RAD51 assay) to see if it could identify ovarian cancer patients whose tumors are vulnerable to the drug olaparib, even if they don't have BRCA gene mutations. The goal was to find a larger group of patients who might benefit from this treatmen…
Matched conditions: HOMOLOGOUS RECOMBINATION DEFICIENCY
Phase 2 • Sponsor: Leiden University Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC