High-grade glioma (HGG)
Clinical trials for High-grade glioma (HGG) explained in plain language.
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Can a new biologic shrink brain tumors before surgery?
Disease control Not yet recruitingThis trial is testing whether giving tarlatamab before and after surgery is safe and feasible for people with recurrent high-grade glioma, an aggressive brain cancer. Participants receive tarlatamab infusions before their tumor is removed, then continue treatment after surgery. T…
Matched conditions: HIGH-GRADE GLIOMA (HGG)
Phase 1 • Sponsor: Vall d'Hebron Institute of Oncology • Aim: Disease control
Last updated Aug 28, 2026 00:00 UTC
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Can a pill reach the brain and fight tumors?
Disease control Not yet recruitingThis trial tests an oral drug called JBI-778 in people with brain metastases, leptomeningeal disease, or recurrent high-grade glioma. The drug is designed to block a protein that may help tumors grow. The study aims to find the safest dose and see if the drug can shrink tumors or…
Matched conditions: HIGH-GRADE GLIOMA (HGG)
Phase 1/2 • Sponsor: Jubilant Therapeutics Inc. • Aim: Disease control
Last updated Aug 09, 2026 00:00 UTC
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Can a tiny implant trap brain tumor cells and make radiation work better?
Disease control Not yet recruitingThis pilot trial is testing a medical device called GlioHook, which is implanted in the brain after surgery to remove a high-grade glioma. The implant is designed to trap any remaining tumor cells and make follow-up radiotherapy more effective. The study includes about 15 adults …
Matched conditions: HIGH-GRADE GLIOMA (HGG)
Sponsor: Batea Oncology • Aim: Disease control
Last updated Jul 29, 2026 00:00 UTC
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Experimental drug cocktail takes on childhood brain cancers
Disease control Not yet recruitingThis study tests two immunotherapy drugs, fianlimab and cemiplimab, in children and young adults with recurrent high-grade glioma or ependymoma. The goal is to see if the combination is safe and can shrink tumors or slow their growth. Participants will receive the drugs before an…
Matched conditions: HIGH-GRADE GLIOMA (HGG)
Phase 1/2 • Sponsor: Regeneron Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC