HGG
Clinical trials for HGG explained in plain language.
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Sound wave helmet could boost brain cancer treatment
Disease control Recruiting nowThis early-stage trial tests a special helmet that uses focused ultrasound to temporarily open the blood-brain barrier in people with glioblastoma, a severe brain cancer. The goal is to see if this approach is safe and can help standard chemotherapy reach the tumor more effective…
Matched conditions: HGG
Phase: PHASE1 • Sponsor: Sunnybrook Health Sciences Centre • Aim: Disease control
Last updated May 22, 2026 13:55 UTC
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New pill targets hard-to-treat cancers with BRAF mutations
Disease control Recruiting nowThis study tests a drug called FORE8394 (plixorafenib) in people with advanced solid tumors or brain tumors that have certain BRAF gene changes. The goal is to see if the drug can shrink tumors and control the disease. About 254 participants aged 10 and older will take the drug b…
Matched conditions: HGG
Phase: PHASE2 • Sponsor: Fore Biotherapeutics • Aim: Disease control
Last updated May 20, 2026 11:54 UTC
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New pill combo targets Hard-to-Treat cancers in early trial
Disease control Recruiting nowThis study tests a new experimental drug (PF-07799544) combined with another drug (PF-07799933) in adults with advanced solid tumors that have a specific gene change called BRAF V600. The goal is to see if the combination is safe and can shrink or control the cancer. Participants…
Matched conditions: HGG
Phase: PHASE1 • Sponsor: Pfizer • Aim: Disease control
Last updated May 06, 2026 16:13 UTC
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Glowing drug lights up brain tumors during surgery
Knowledge-focused Recruiting nowThis study tests a special version of the cancer drug nivolumab that has a fluorescent dye attached, called nivo800. The dye makes the drug glow under a special camera, allowing surgeons to see where the drug goes in the brain during tumor removal. The goal is to learn how well t…
Matched conditions: HGG
Phase: EARLY_PHASE1 • Sponsor: Eben Rosenthal • Aim: Knowledge-focused
Last updated May 26, 2026 07:08 UTC