GVHD, acute
Clinical trials for GVHD, acute explained in plain language.
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Can adding methotrexate to steroids tame a dangerous transplant complication?
Disease control CompletedThis phase III trial tests whether adding low-dose methotrexate to standard corticosteroid treatment works better than steroids alone for adults who develop acute graft-versus-host disease after a stem cell transplant. Participants receive either methotrexate or a placebo alongsi…
Matched conditions: GVHD, ACUTE
Phase 3 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Disease control
Last updated Sep 20, 2026 00:00 UTC
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New drug shows promise in controlling transplant complications
Disease control CompletedThis study tested a new drug called EQ001 in 30 people who developed acute graft-versus-host disease (aGVHD) after a stem cell transplant. aGVHD is a serious condition where donor immune cells attack the patient's body. The goal was to see if EQ001 is safe and can help control th…
Matched conditions: GVHD, ACUTE
Phase 1/2 • Sponsor: Biocon Limited • Aim: Disease control
Last updated Jun 27, 2026 13:07 UTC
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New drug combo shows promise in preventing transplant complications
Disease control CompletedThis early-stage study tested whether adding a drug called BMS-986004 to standard immune-suppressing medicine could help prevent acute graft-versus-host disease (GVHD) in 45 adults with blood cancers or disorders receiving a stem cell transplant. GVHD occurs when donor immune cel…
Matched conditions: GVHD, ACUTE
Phase 1 • Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC
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Blood test may spot deadly transplant complication earlier
Diagnosis CompletedThis completed study looked at whether certain proteins in the blood (called biomarkers) can help predict acute graft-versus-host disease (aGVHD) in 500 patients who had a stem cell transplant for blood cancers. Researchers measured levels of REG3, ST2, IL-6, IL-8, and TNF R ever…
Matched conditions: GVHD, ACUTE
Sponsor: Chinese PLA General Hospital • Aim: Diagnosis
Last updated Jun 27, 2026 12:28 UTC