Graft-versus-host disease(GVHD)
Clinical trials for Graft-versus-host disease(GVHD) explained in plain language.
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New drug cocktail aims to tame deadly transplant complication
Disease control Recruiting nowThis phase 3 trial compares two drug combinations given after a stem cell transplant to prevent graft-versus-host disease (GVHD), a serious complication where donor cells attack the patient's body. The study will enroll 572 adults with blood cancers like leukemia or myelodysplasi…
Matched conditions: GRAFT-VERSUS-HOST DISEASE(GVHD)
Phase 3 • Sponsor: Incyte Corporation • Aim: Disease control
Last updated Jun 27, 2026 12:35 UTC
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New drug cocktail aims to tame deadly transplant complication
Disease control Recruiting nowThis study tests whether adding a new oral drug (ivarmacitinib) to standard medicines can prevent a serious complication called graft-versus-host disease (GVHD) after a stem cell transplant from a female donor who has given birth. About 82 adults with blood cancers will receive t…
Matched conditions: GRAFT-VERSUS-HOST DISEASE(GVHD)
Phase 2 • Sponsor: Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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Lower-Dose drug may make stem cell transplants safer for blood cancer patients
Disease control Recruiting nowThis study tests whether a lower dose of the drug cyclophosphamide can prevent graft-versus-host disease (GVHD) after a stem cell transplant for blood cancers. GVHD is a serious complication where donor cells attack the patient's body. The trial will enroll 41 adults and give the…
Matched conditions: GRAFT-VERSUS-HOST DISEASE(GVHD)
Phase 2 • Sponsor: Milton S. Hershey Medical Center • Aim: Disease control
Last updated Jun 27, 2026 12:03 UTC
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Can a lower drug dose improve life after stem cell transplant for older adults?
Disease control Recruiting nowThis study is for adults aged 60 and older with blood cancers who need a stem cell transplant. It compares a standard high dose of a drug (cyclophosphamide) with a lower dose, both combined with another drug (sirolimus), to prevent graft-versus-host disease (GVHD). The goal is to…
Matched conditions: GRAFT-VERSUS-HOST DISEASE(GVHD)
Phase 2 • Sponsor: University of Nebraska • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC