Glioblastoma, IDH-wildtype
Clinical trials for Glioblastoma, IDH-wildtype explained in plain language.
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Immunotherapy shows promise for tough brain cancers
Disease control OngoingThis study tests whether two immunotherapy drugs, ipilimumab and nivolumab, can shrink or slow the growth of recurrent high-grade gliomas (brain tumors) that have a high number of genetic mutations. About 37 adults with recurrent WHO grade 4 glioma will receive these drugs. The g…
Matched conditions: GLIOBLASTOMA, IDH-WILDTYPE
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Sep 02, 2026 00:00 UTC
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Could a transplant drug boost brain cancer treatment?
Disease control OngoingThis early-phase trial tests adding mycophenolate mofetil, a drug usually used to prevent organ rejection, to standard chemotherapy and radiation for glioblastoma. The goal is to find a safe dose and see if the combination can make tumor cells more sensitive to treatment. About 6…
Matched conditions: GLIOBLASTOMA, IDH-WILDTYPE
Phase 1 • Sponsor: Northwestern University • Aim: Disease control
Last updated Aug 28, 2026 00:00 UTC
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New drug aims to shrink brain tumors by blocking cancer's growth signal
Disease control OngoingThis early-phase trial tests a drug called WSD0922-FU in 56 people with certain brain cancers (glioblastoma, anaplastic astrocytoma) or lung cancer that has spread to the brain or spinal cord. The drug blocks a protein called EGFR that helps cancers grow, and is designed to reach…
Matched conditions: GLIOBLASTOMA, IDH-WILDTYPE
Phase 1 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Aug 12, 2026 00:00 UTC
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Ultrasound device opens brain barrier to attack deadly tumors
Disease control OngoingThis trial tests an implantable ultrasound device that temporarily opens the blood-brain barrier, allowing chemotherapy to reach brain tumors. It includes 57 adults with recurrent glioblastoma who have already tried 1-2 treatments. The goal is to find a safe dose and see if this …
Matched conditions: GLIOBLASTOMA, IDH-WILDTYPE
Phase 1/2 • Sponsor: Northwestern University • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC