Drug resistant epilepsy

This trial tests the safety of a new device called the NAO.VNS System for people with drug-resistant epilepsy, a condition where seizures continue despite medication. The device is implanted and delivers vagus nerve stimulation, which may help reduce seizure activity. Researchers…

This study asks whether adding a medically supervised ketogenic diet to occupational therapy can help children aged 4 to 7 with ARX gene mutations and drug-resistant epilepsy. Twenty children will take part: half follow the ketogenic diet while the other half do not, and both gro…

Researchers are testing whether low-dose intravenous ketamine can reduce seizures in adults with drug-resistant epilepsy, meaning their seizures have continued despite trying at least two anti-seizure medications. Twelve participants receive ketamine three times a week for two we…

This trial tests whether an ultrasound-guided nerve block (intermediate cervical plexus block) using bupivacaine can reduce pain and the need for opioid painkillers after vagus nerve stimulator implantation. Adults with drug-resistant epilepsy scheduled for this surgery are rando…

This small study tested a leucine-enriched amino acid powder given alongside a classic ketogenic diet in 4 people with drug-resistant epilepsy. The main goal was to see if the powder is safe and tolerable. Researchers also checked if it helped with nutrition. Because it was a ver…

This pilot study tested a device called NaviFUS that uses focused ultrasound to stimulate the brain in 12 adults with drug-resistant epilepsy. The goal was to see if it is safe and can reduce seizure frequency. Participants kept seizure diaries and reported any side effects over …

This study looked at whether tiny molecules in the blood, called microRNAs, can identify epilepsy patients who have dangerous drops in oxygen during seizures. Researchers compared 50 drug-resistant epilepsy patients undergoing video-EEG monitoring, splitting them into those who h…