COLORECTAL (COLON OR RECTAL) CANCER

This early-stage study tests a new drug called CBI-1214 in people with advanced colorectal cancer that has not responded to standard treatments. The goal is to find a safe dose and see if the drug can shrink tumors. About 80 participants will receive the drug through an IV, and r…

This study tests whether a new drug called RC148, when combined with chemotherapy, works better than the current standard treatment (bevacizumab plus chemo) for people with advanced colorectal cancer that cannot be removed by surgery. About 80 adults aged 18-75 with measurable tu…

This study tests a surgical procedure called utero-ovarian transposition (UOT) to protect fertility in women aged 18-40 with pelvic cancers who need radiation therapy. The surgery moves the uterus and ovaries away from the radiation area to preserve their function. Researchers wi…

This study compares two drugs, lidocaine and ketamine, given during colorectal cancer surgery to see which better reduces inflammation (measured by a marker called IL-6). Fifty adults having open surgery will be randomly assigned to receive one of the drugs for 24 hours. The goal…

This study tests whether using hypnosis during a screening colonoscopy helps people complete the procedure with less anxiety and pain. About 600 adults getting a routine colonoscopy for colorectal cancer detection will be randomly assigned to either standard care or hypnosis. The…

This early-phase study looks at how a non-invasive sound wave treatment called histotripsy affects the immune system in 12 people with colorectal cancer that has spread to the liver. Researchers will take blood samples before and after treatment to measure changes in immune T-cel…