Car-T cell therapy
Clinical trials for Car-T cell therapy explained in plain language.
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Could a simple drug tame the dangerous side effects of CAR-T cancer therapy?
Disease control CancelledThis study tests whether giving the drug anakinra early can prevent severe cytokine release syndrome (CRS) in children and young adults with B-cell acute lymphoblastic leukemia (B-ALL) who are receiving CAR-T cell therapy. Participants receive anakinra at the first sign of fever,…
Matched conditions: CAR-T CELL THERAPY
Phase 1/2 • Sponsor: Kevin McNerney • Aim: Disease control
Last updated Aug 15, 2026 00:00 UTC
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CAR-T therapy aimed at tough kidney disease in kids — but trial never started
Disease control CancelledThis was a planned early-stage trial to test whether anti-CD19 CAR-T cells could safely help children with multi-drug resistant nephrotic syndrome, a serious kidney condition. The study was withdrawn before any patients were enrolled, so no data on safety or effectiveness were co…
Matched conditions: CAR-T CELL THERAPY
Phase 1 • Sponsor: The Children's Hospital of Zhejiang University School of Medicine • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Promising CAR-T trial for kids with rare vasculitis pulled before start
Disease control CancelledThis trial aimed to test whether anti-CD19 CAR-T cells could safely and effectively treat children with refractory ANCA-associated vasculitis, a rare autoimmune disease. The study was withdrawn before enrolling any participants, so no results are available. It was designed for ch…
Matched conditions: CAR-T CELL THERAPY
Sponsor: The Children's Hospital of Zhejiang University School of Medicine • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Engineered immune cells take on lupus in early trial
Disease control OngoingThis early-stage study tests a new treatment for people with refractory systemic lupus erythematosus, a severe form of lupus that doesn't improve with standard medicines. The treatment uses the patient's own immune cells, modified to target and attack faulty immune cells that dri…
Matched conditions: CAR-T CELL THERAPY
Phase 1 • Sponsor: The Children's Hospital of Zhejiang University School of Medicine • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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Real-World data shows promise for CNCT-19 in tough leukemia
Disease control OngoingThis study looks at how well a treatment called CNCT-19 works for adults with a type of blood cancer called B-cell acute lymphoblastic leukemia (ALL). Researchers will review medical records from 275 patients across multiple hospitals in China to see how many achieve remission an…
Matched conditions: CAR-T CELL THERAPY
Sponsor: Ruijin Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC